67例呼吸暂停早产儿血清茶碱浓度与剂量分析  

Relationship of Dose and Serum Concentration of Theophylline in 67 Cases of Premature Infant with Apnea

作　　者：张慧芬[1] 王珏[1] 倪映华[1] 黄云[1] 郦柏平[1] 

机构地区：[1]浙江大学医学院附属儿童医院,杭州310003

出　　处：《中国药学杂志》2010年第21期1652-1655,共4页Chinese Pharmaceutical Journal

基　　金：浙江省科技计划面上科研项目(2008C33023)

摘　　要：目的研究茶碱治疗早产儿呼吸暂停的量效关系,为临床呼吸暂停早产儿合理应用茶碱类药物提供参考。方法回顾分析我院近两年来采用荧光偏振免疫分析法测定的67例呼吸暂停早产儿血清茶碱浓度及其使用的氨茶碱剂量。结果呼吸暂停早产儿的血清茶碱浓度与剂量呈正相关,但个体之间差异较大;临床疗效较好的氨茶碱日维持剂量为(2.9±0.8)mg.kg-1.d-1,相应的质量浓度为(4.3±1.1)mg.L-1;血清茶碱浓度与矫正胎龄无关,相关系数r=0.05(P>0.05),而茶碱日维持剂量与矫正胎龄显著相关,相关系数r=0.27(P<0.05)。结论临床上在使用茶碱治疗早产儿呼吸暂停时,应监测血药浓度并实行个体化给药,建议血清茶碱浓度维持在4 mg.L-1左右。OBJECTIVE To study the dose-effect relationship of theophylline treatment for premature infant with apnea for clinical application of apnea in premature infant.METHOD The concentration of serum theophylline and dose detected by fluorescence polarization immunoassay（FPIA） were analyzed in 67 cases of premature infant with apnea in the last two years.RESULTS The theophylline concentration was positively correlated with the dose.However,there were significant differences along individuals.The proper maintenance dose with good clinical effect was（2.9±0.8） mg·kg-1·d-1.The corresponding trough concentration was（4.3±1.1） mg·L-1.Theophylline trough concentration showed no relationship with the corrected gestational age（P0.05）.Meanwhile,the maintenance dose of theophylline was significantly correlated with corrected gestational age（P0.05）.CONCLUSION It is suggested to monitor the serum concentration and carry out individual administration in the clinical application of theophylline in the treatment of apnea in premature infant.It is recommended to maintain serum theophylline trough concentration in the 4 mg·L-1.

关 键 词：茶碱 血药浓度 维持剂量 早产儿 呼吸暂停 

分 类 号：R969.1[医药卫生—药理学]