烯丙基-β-环糊精基手性毛细管电色谱整体柱的一步法制备及其性能  

One-step preparation and properties of allyl-β-cyclodextrin chiral monolithic capillary electrochromatography column

作　　者：李英杰[1,2] 梁辉[2] 吕仁江[2] 张春雨[2] 张凌怡[3] 付宏刚[1] 张维冰[2,3] 

机构地区：[1]黑龙江大学化学化工与材料学院,哈尔滨150080 [2]齐齐哈尔大学化学与化学工程学院,齐齐哈尔161006 [3]华东理工大学化学与分子工程学院,上海200237

出　　处：《中国科学：化学》2010年第11期1682-1687,共6页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(20675083);国家重点基础研究发展规划(o1CB5m202);科技部“十一五”国家科技支撑计划重大项目(2006BAF07B03)资助

摘　　要：以烯丙基-β-环糊精、甲基丙烯酸缩水甘油酯和乙二醇二甲基丙烯酸酯为功能单体,一步键合制备了环糊精聚合物毛细管整体柱.在电色谱模式下18种氨基酸对映体得到成功分离.研究发现,将修饰的环糊精衍生物作为功能单体制备出的毛细管整体柱对疏水性,含氨基和苯环的手性化合物具有良好的保留行为,并具有良好的稳定性和重现性.新型电色谱柱也被应用于手性药物的分离.Allyl-β-cyclodextrin chiral monolithic capillary electrochromatography column was prepared by one-step reaction with allyl-β-cyclodextrin（allyl-β-CD） ,glycidyl methacrylate and ethylene glycol dimethacrylate as functional monomers.In capillary electrochromatography（CEC） mode,18 kinds of amino acid enantiomers were separated successfully.The study found that the capillary monolithic column prepared by modified CD derivatives as the functional monomer had good retention ability to hydrophobic chiral compounds containing amido or benzene ring.Meanwhile,it had good stability and reproducibility.The new column had also been applied to separation of chiral drugs.

关 键 词：毛细管电色谱 烯丙基-β-环糊精 整体柱 氨基酸 手性固定相 

分 类 号：O657.7[理学—分析化学]