丙泊酚与七氟醚复合麻醉对肝炎肝硬化患者术后肝肾功能的影响  

The effect of propofol combined with sevoflurane on renal and hepatic function in Patients with liver cirrhosis

作　　者：张建[1] 卓九五[1] 廖建梅[1] 王佳[1] 殷国平[1] 

机构地区：[1]东南大学附属第二医院麻醉科,南京市210003

出　　处：《临床麻醉学杂志》2010年第10期866-868,共3页Journal of Clinical Anesthesiology

摘　　要：目的探讨丙泊酚与七氟醚复合麻醉对肝炎肝硬化患者术后肝肾功能的影响。方法选择60例ASAⅠ或Ⅱ级,肝炎肝硬化门脉高压拟行脾切断流术的患者,随机均分为七氟醚组(A组)、丙泊酚组(B组)和丙泊酚复合七氟醚组(C组)。三组患者分别采用七氟醚吸入、单纯丙泊酚静脉输注和丙泊酚复合七氟醚维持麻醉,维持患者生命体征平稳。记录术前、术后第1、3、5天肝、肾功能指标。结果三组患者术后第1、3、5天肝脏酶显著增高(P<0.05),在术后第1天达到高峰,总胆红素术后第3天达高峰,白蛋白术后第1天显著降低(P<0.05),术后第3天和第5天与术前比较差异无统计学意义,三组患者均无肝功能衰竭。术后肾功能指标肌酐、尿素氮组内、组间比较差异无统计学意义。结论丙泊酚与七氟醚复合麻醉对肝炎肝硬化行脾切断流术患者术后早期肝功能有轻度影响,对肾功能无明显影响。Objective To investigate the effect of propofol combined with sevoflurane on renal and hepatic function in liver cirrhosis patients. Methods Sixty ASA class I or II liver cirrhosis patients scheduled for porta-azygous disconnection were assigned into three groups with 20 cases each. They received sevoflurane, propofol and propofol combined with sevoflurane respectively during the operation. Renal and hepatic functions were detected before and on the 1st, 3rd, and 5th postoperative day. Results There was no significant difference in hepatic function among the three groups. No patients developed into hepatic failure. Blood urea nitrogen and serum creatinine in all the patients were within the normal range. Conclusion Propofol combined with sevoflurane has no significant effect on the renal and hepatic function in patients with liver cirrhosis underwent portaazygous disconnection.

关 键 词：七氟醚 丙泊酚 全身麻醉 复合麻醉 肝肾功能 

分 类 号：R614[医药卫生—麻醉学]