O-GlcNAc修饰与相关疾病的发病机理  

O-GlcNAc modification and associated diseases' pathogenesis

作　　者：王斌 谢翀 李静[2] 胡江林 

机构地区：[1]山东胜利股份有限公司,济南250101 [2]南开大学药学院,天津300071

出　　处：《生命的化学》2010年第5期680-684,共5页Chemistry of Life

摘　　要：O-(连接)-N-乙酰葡糖胺(O-GlcNAc)糖基化修饰(O-GlcNAcylation)是一种存在于细胞核与细胞质中的蛋白质翻译后修饰。与磷酸化相似,它参与细胞内的信号传递,并与神经退行性疾病、Ⅱ型糖尿病、癌症等许多疾病的发病机理密切相关。O-GlcNAcylation is a newly discovered protein post-translational modification in nucleus and cytoplasm.Similar to phosphorylation,O-GlcNAcylation plays an important role in cell signal transduction and may be associated with many human diseases such as degenerative diseases,type Ⅱ diabetes and cancer.

关 键 词：N-乙酰葡萄糖胺 神经退行性疾病 Ⅱ型糖尿病 癌症 

分 类 号：Q50[生物学—生物化学]