成纤维细胞生长因子受体4的研究  

Fibroblast growth factor receptor 4 and its signaling pathways

作　　者：孔祥鑫[1,2] 王会岩[1,2] 李校堃[1,2] 

机构地区：[1]吉林农业大学生物反应器与药物开发教育部工程研究中心,长春130118 [2]吉林农业大学生命科学学院,长春130118

出　　处：《生命的化学》2010年第5期717-722,共6页Chemistry of Life

基　　金：吉林省科技发展计划项目(20080712);长春市净月科技项目(2008B003)资助

摘　　要：成纤维细胞生长因子受体4(fibroblast growth factor receptor4,FGFR4)是成纤维细胞生长因子受体家族中较晚被发现的一类跨膜酪氨酸激酶受体,通过与成纤维细胞生长因子结合,启动PLC、Ras等多条信号转导途径将胞外信号传递到细胞内,主要参与胚胎发育、血管生成、创伤愈合、组织分化和修复等重要生理进程,对乳腺癌、肝癌等癌症的发生发展起着重要作用,并成为癌症前期极好的预测因子及治疗学中的有效靶点。本文主要概述了FGFR4的信号转导过程及病理学研究进展。Fibroblast growth factor receptor 4 （FGFR4） is a transmembrane tyrosine kinase receptor,which was found in the fibroblast growth factor receptor family.FGFR4 could transmit extracellular signal into cell through switching on multiple signal transduction pathways when associating with the fibroblast growth factor.It effects on fetal development,vascularization,healing of wound,tissue differentiation and rehabilitation,and also plays an important role in the development and aggressiveness of some cancers,which makes FGFR4 be an excellent predictor for pre-cancerous and an efficient target for therapeutics.The signal transduction process and advances in FGFR4 pathology were mainly overviewed in this paper.

关 键 词：FGFR4 信号通路 癌症 多态性 

分 类 号：Q26[生物学—细胞生物学]