代谢组学及其在药物毒性评价中的应用  

Metabonomics and its applications in the evaluation of drug toxicity

作　　者：刘瑞媛[1] 叶华[1] 谢婷[1] 冯璐璐[1] 李发荣[1] 

机构地区：[1]陕西师范大学生命科学学院,西安710062

出　　处：《生命的化学》2010年第5期774-778,共5页Chemistry of Life

基　　金：陕西省自然科学基金项目(SJ08-ZT10)资助

摘　　要：建立可靠的药物毒性评价方法是药物开发中的重要任务之一。近几年发展起来的代谢组学可以对生物体内的代谢产物变化进行定性定量分析,并对整体代谢轮廓进行模式识别,为药物毒性评价和毒性作用机制的研究提供了新的技术手段。本文就代谢组学、代谢组学研究方法及其在药物毒性评价中的应用进行了综述。Establishing a reliable assessment of drug toxicity is one of the most important scientific tasks in drug development.With the development of metabonomics,the technology has been established to analyze all metabolites in organism qualitatively and quantitatively,and recognized the metabolic profile in entirety.This approach has proved to be a novel and powerful tool for the evaluation of drug toxicity and its mechanism.This review contributes to a brief summery and comments on the metabonomics,and its application in the evaluation of drug toxicity.

关 键 词：代谢组学 毒性评价 肝毒性 肾毒性 

分 类 号：R96[医药卫生—药理学]