耐多药肺结核患者耐药情况及影响因素  

Drug resistance and its influencing factors among patients with multidrug-resistant tuberculosis

作　　者：张明 娄培安[2] 刘林 陈培培[2] 张亚 刘杰 李军政 

机构地区：[1]江苏省邳州市疾病预防控制中心,221300 [2]江苏省徐州市疾病预防控制中心

出　　处：《中国公共卫生》2010年第11期1439-1440,共2页Chinese Journal of Public Health

基　　金：2007-2008年度江苏省卫生厅预防医学科研课题(Y200714);徐州市2007年科技计划项目(XM07C096)

摘　　要：目的探讨耐多药肺结核(MDR-TB)患者的成因。方法对结核菌药敏试验阳性的100例MDR-TB患者进行耐药现状、抗结核治疗情况、肺部病变及合并症分析。结果 100例MDR-TB患者中,96例(96.0%)患者未按照早期、联合、适量、规律、全程的肺结核治疗原则治疗,耐多药者男性85例,多于女性的15例,>60岁老人占51.0%。耐≥3种抗结核药物的患者占92.0%;MDR-TB发生与性别、文化程度、人均收入、年龄、结核病治疗史有关。结论 MDR-TB发生主要与患者不规则治疗有关,同时受性别、文化程度、人均收入、年龄、结核病治疗史的影响。Objective To investigate the status of drug resistance and its influencing factors among patients with multi-drug resistant tuberculosis（MDR-TB）.Methods The status of drug resistance,treatment of tuberculosis,lung lesions and complications of 100 MDR-TB patients were analyzed with TB drug susceptibility test.Results Of all MDR-TB patients,96（96.0%） did not follow the principle of TB treatment（early,joint,adequate,regular and full treatment）.Among the pa-tients,there were 85 men and 15 women with 51.0% of patients more than 60 years old.There were 92.0% of the patients with resistance to three kinds of anti-TB drug and 43.0% of them with complications.Sex,educational level,per capita in-come,age,history of the tuberculosis treatment were associated with MDR-TB.Conclusion The incidence of MDR-TB is associated with irregular treatment,as well as with gender,educational level,per capita income,age,history of tuberculosis treatment.

关 键 词：抗药性 多药耐药 结核/肺 

分 类 号：R183.3[医药卫生—流行病学]