钙通道阻滞药降压疗效影响因素分析  

Analysis on Influencing Factors for Antihypertensive Efficacy of Calcium Channel Blocker

作　　者：朱立勤[1,2,3] 孙鹤[2] 肖怡然[3] 李敬永[3] 

机构地区：[1]天津市第一中心医院,天津市300192 [2]天津大学药物科学与技术学院,天津市300072 [3]天津医科大学,天津市300070

出　　处：《中国药房》2010年第42期3994-3996,共3页China Pharmacy

摘　　要：目的:对影响钙通道阻滞剂疗效的影响因素进行分析,为临床用药有效治疗高血压提供依据。方法:对86例使用钙通道阻滞药类降压药的患者制定影响降压疗效的影响因素调查量表,根据临床病例提供的数据填写调查量表,并进行包括年龄、性别、血压变化、肝肾功能等因素的Logistic多因素回归分析,找出影响疗效的要因。结果:在钙通道阻滞剂降压疗效的影响因素中,年龄、体质量、病史和吸烟史为要因,影响了钙通道阻滞剂的疗效。结论:临床使用钙通道阻滞剂治疗原发性高血压患者时,体质量正常的患者、病史5年以下的患者和无吸烟史的患者,能够收到更好的降压作用。OBJECTIVE：To analyze the influencing factors for antihypertensive efficacy of calcium channel blocker and to provide reference for effective treatment of hypertension. METHODS：86 patients treated with calcium channel blocker were provided with questionnaire for influencing factors of antihypertensive efficacy. The questionnaires were filled with clinical data including age,sex,blood pressure,liver and kidney function which were analyzed with Logistic regression analysis to identify influencing factors of clinical efficacy. RESULTS：Clinical efficacy of calcium channel blocker was mainly affected by age,weight,medical history and smoking history. CONCLUSION：Calcium channel blocker represents sound effect in hypertensive patients with normal body weight,medical history under 5 years and without smoking history.

关 键 词：钙通道阻滞药 降压药 影响因素 

分 类 号：R969.3[医药卫生—药理学] R972.4[医药卫生—药学]