硫酸沙丁胺醇溶解度的实验测定与预测  

Measurement and Prediction of Solubilities of Salbutamol and its Sulfate

作　　者：陈玉婷[1] 郭伟[1] 孙贤祥[1] 王兆刚[1] 

机构地区：[1]常州大学石油化工学院,江苏常州213164

出　　处：《常州大学学报（自然科学版）》2010年第3期74-78,共5页Journal of Changzhou University：Natural Science Edition

摘　　要：用饱和法测定了沙丁胺醇游离碱在V(水)∶V(甲醇)=0.29∶0.71、V(甲醇)∶V(丙醇)=1∶1、正丙醇等体系,硫酸沙丁胺醇在V(水)∶V(甲醇)=0.29∶0.71、V(甲醇)∶V(丙醇)=1∶1等体系下的溶解度。用4种经验方程对溶解度的实验结果进行了拟合,用UNIFAC模型对实验溶解度的估算进行了研究,提出了ACOH/CH2NH与CH2NH/ACOH基团以及SO42-与ACH、ACOH、ACCH2、ACCH和CH2NH等的基团相互作用新参数,并用于沙丁胺醇、沙丁胺醇游离碱的溶解度预测,预测值的方根均方差(Rs,d)在0.022%-1.910%。The solubilities for salbutamol and its sulfate were measured experimentally by saturation method.The experimental solubility data were fitted with four empirical equations.Prediction of the experimental solubilities for salbutamol and salbutamol sulfate by using the original UNIFAC model was made on the basis of use of the adjustable group interaction parameters proposed in this paper.The predicted solubilities for salbutamol and salbutamol sulfate were close to the measurement values with the root mean standard deviation ranging from 0.022% to 1.910%.

关 键 词：溶解度 饱和法 沙丁胺醇 UNIFAC 溶解度预测 

分 类 号：TQ028.5[化学工程] TQ028.6