龙血竭中龙血素A在大鼠体内的药动学研究  

Study on pharmacokinetics of loureirin A in rats

作　　者：易军[1] 金描真[1] 孙晓博[1] 乔淑娟[1] 

机构地区：[1]广东药学院药科学院,广东广州510006

出　　处：《广东药学院学报》2010年第5期452-454,共3页Academic Journal of Guangdong College of Pharmacy

基　　金：广东省中医药管理局项目(2008178);国家中医药管理局项目(04-05ZP49)

摘　　要：目的考察龙血竭中龙血素A在大鼠体内的药动学行为。方法按100 g大鼠给予龙血竭250 mg灌胃给药,测定不同时间点的血药浓度,并以3P97软件计算其药动学参数。结果龙血素A的Ka为(1.46±0.19)h-1,t1/2(Ka)为(0.48±0.06)h,t1/2(K)为(2.59±0.67)h,tmax为(2.00±0.55)h,Cmax为(1.13±0.24)μg.mL-1,AUC为(2.84±0.68)μg.h.mL-1。结论龙血素A在大鼠体内符合线性动力学一室开放模型,吸收较快。Objective To study on pharmacokinetics of loureirin A in rats.Methods The blood samples were collected at a series of time points after an oral administration of Dragon′s blood to rats（2.5 g·kg-1）,and were analyzed by HPLC.Pharmacokinetic parameters were valuated by 3P97 software.Results Pharmacokinetic parameters of loureirin A were as follows：Ka（1.46±0.19） h-1,t1/2（Ka）（0.48±0.06） h,t1/2（K）（2.59±0.67） h,tmax（2.00±0.55） h,Cmax（1.13±0.24） μg·mL-1,AUC（2.84±0.68） μg·h·mL-1.Conclusion The results demonstrated that the pharmacokinetics of loureirin A was consistent with one-compartment model,which was absorbed and distributed rapidly in rats.

关 键 词：龙血竭 龙血素A 高效液相色谱法 大鼠 药动学 

分 类 号：R285.5[医药卫生—中药学]