1997年12月至2009年12月成人接种卡介苗对支气管哮喘防控作用监测研究  

Monitoring research on the role of BCG vaccination for adults on the prevention and control of bronchial asthma in 1997.12～2008.12

作　　者：祖军[1] 顾鸣[1] 胡道虎[1] 沈良儒[1] 陈建军[1] 薛同明 张以祥 唐兆标[1] 胡遐诉[1] 顾春湘[1] 许柏林[1] 叶隆昌[1] 

机构地区：[1]南京市第一医院集团泗洪县分金亭医院呼吸科,223900 [2]涟水县疾病预防控制中心,223400 [3]洪泽县疾病预防控制中心,223100

出　　处：《中华哮喘杂志（电子版）》2010年第4期193-198,共6页Chinese Journal of Asthma(Electronic Version)

基　　金：淮安市科技局(S9334);淮安市科技局(HAS08030);江苏省卫生厅[苏卫科(93)28]

摘　　要：目的探讨成人接种卡介苗能否预防支气管哮喘(简称哮喘)发生和控制已患哮喘急性发作。方法以分层整群随机抽样确定科研点的县、乡,以乡辖村为单位分为研究组和对照组,对村中20～55岁非肿瘤、结核病现症患者的自愿村民按性别、年龄分别配对,对研究组人群进行卡介苗接种,每6个月1次连续3次;依靠县、乡、村三级防疫网络,对哮喘的发生和已患哮喘的发作进行监测。结果抽得4个乡、83个村,共有哮喘患者1406例,患病率为1.3%(1406/108189);纳入监测的20～55岁村民共24830人,哮喘患者149例,患病率0.6%,其中研究组81例,对照组68例;在1997年12月至2009年12月监测期间研究组死亡3例,尚存的78例急性发作35例,共计233次;对照组死亡7例,尚存的61例发作59例,共计2131次。哮喘患者的急性发作率比较及发作次数(人次)比较研究组与对照组间的差异均有统计学意义(χ2=42.07,P<0.01;t=9.46,P<0.01);研究组原非哮喘患者12334人中已经死亡432人,新发哮喘13例,哮喘发生、发作共计167次;对照组原非哮喘患者12347人中已经死亡511人,新发哮喘39例,哮喘发生、发作共计1907次。哮喘发病率比较及发生、发作的次数(人次)比较研究组与对照组间的差异亦均有统计学意义(χ2=13.17,P<0.01;t=6.31,P<0.01)。结论成人接种卡介苗对哮喘的发生有一定预防作用,对哮喘急性发作有一定治疗、控制作用。Objective Discuss the adults vaccinated BCG whether can prevent the occurrence of bronchial asthma （asthma）,and control them from suffering from the recrudescence of the original asthma.Methods Determine the county and town as the scientific research point by random sampling,and then use the villages in the town as units to divide the study group and control group randomly.Match the voluntary villagers who have no tumor but tuberculosis from 20 to 55 years old by the gender and age,and vaccinate the BCG to the villagers in the study group every six months for three times.Then depend on the county,town and village epidemic prevention net to monitor the occurrence and recrudescence of the asthma.Results There were 1 406 people in the 4 towns which has 83 villages,and the prevalence rate of asthma is 1.3% （1 406/108 189）;while the villagers from 20 to 55 who are beyond the monitor is about 24 830,among which there were 149 people who are suffering from asthma,and the prevalence rate was about 0.6%.There were 81 people divided into the study group and 68 people into the control group.Within the monitoring time from December 1997 to December 2009,in the study group,there were 3 people died,and among the rest 78 people,35 people suffer from the recrudescence of asthma,233 times in total,there were 7 people died in the control group,and among the rest 61 people,59 people suffer form the recrudescence of asthma,2 131 times in total.Comparing the attack rate and the attack times,there was obvious difference exist between the study rate and control rate（χ2=42.07,P0.01;t=9.46,P0.01）.There were 432 people died in the 12 334 people who were original non-asthmatic patients in the group which vaccinated BCG,and there were 13 newly issued asthma cases,the occurrence and recrudescence of asthma in total was 167.There were 511 people died in the 12 347 people who were original non-asthmatic patients in the control group,and there were 39 newly issued asthma cases,the occurrence and recrudescence of asthma in total is

关 键 词：卡介苗 支气管哮喘 发生/发作 监测研究 预防和控制 

分 类 号：R562.25[医药卫生—呼吸系统]