乌苏里藜芦碱抗血栓作用机制的研究  

Study on Mechnism of Antithrombotic Effect of Veratrum Nigrum L.var.Ussurience Nakai Alkaloids

作　　者：杨静娴[1] 史相国 徐志立[1] 闫宇辉[1] 吕莉[3] 韩国柱[3] 

机构地区：[1]辽宁中医药大学药学院,116601 [2]大连市第七人民医院,116023 [3]大连医科大学药学院,116044

出　　处：《中国医药指南》2010年第32期177-178,共2页Guide of China Medicine

基　　金：辽宁省教育厅科研项目(2004D102)

摘　　要：目的研究乌苏里藜芦碱(VnA)抗血栓作用的机制。方法建立血瘀大鼠模型,检测VnA治疗前后血小板聚集率及血浆TXA2和PGI2水平的变化。结果静脉注射VnA可显著降低血小板聚集率,使血浆TXA2水平降低,PGI2水平升高。结论 VnA可显著抑制血小板聚集,其机制可能与升高血浆PGI2与TXA2比值有关。Objective To study the mechanism of antithrombotic effect of Veratrum nigrum L. var. ussurience Nakai alkaloids （VnA）. Methods Blood stasis models were made and treated with VnA intravenously. The blood samples were collected and tested for platelet aggregation, concentrations of plasma TXA2 and PGI2. Results In comparison with control blood stasis model, V nA treatment significantly inhibited platelet aggregation, decreased plasma TXA2, and increased plasma PGI2. Conclusion VnA increased the ratio of PGI2 and TXA2, thereby inhibiting platelet aggregation.

关 键 词：乌苏里藜芦碱 抗血栓作用 血小板 前列腺素I2 血栓素A2 

分 类 号：R282.710.7[医药卫生—中药学]