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机构地区:[1]山东省威海市文登中心医院消化科,264400
出 处:《中国医药指南》2010年第32期180-182,共3页Guide of China Medicine
摘 要:目的通过对临床资料的分析,总结原发性胆汁性肝硬化(PBC)患者的临床表现和病理特征。方法对98例PBC患者的临床资料进行回顾性分析。结果本组98例原发性胆汁性肝硬化患者,女性占据了91例,远远高于男性;年龄在30~62岁,常见的临床症状是疲劳、倦怠,也会出现皮肤瘙痒、黄疸,伴有高胆红素血症、高球蛋白血症、碱性磷酸酶和γ谷氨酰转肽酶升高、ALT、AST异常等,并且存在自身的抗体,经检测大部分的患者的抗线粒体抗体或抗线粒体M2亚型抗体呈阳性。结论 PBC好发于中年女性,此病对肝脏的的损伤较为严重,经确诊后往往已到达晚期,预后较差。因此早期的诊断和积极的治疗,不仅可以延缓病程的发展,而且一定程度上可以改善预后。Objective To analyze clinical data, summary of primary biliary cirrhosis (PBC) in patients with clinical and pathological features. Methods 98 patients with PBC patients were retrospectively analyzed. Results 98 patients with primary biliary cirrhosis patients, women accounted for 91 cases, much higher than men; aged 30 to 62 years old, common symptoms are fatigue, malaise, there will be itching, jaundice, associated with hyperbilirubinemia, high hypergammaglobulinemia, alkaline phosphatase, and a glutamyl elevated GGT, ALT, AST abnormalities, and there is its own antibodies, the majority of patients testedanti-mitochondrial M2 antibody or anti-mitochondrial antibody-positive subtype. Conclusion PBC occurs in middle-aged women, the disease of the liver injury is more serious, often after diagnosis has been reached by the late, prognosis is poor.Therefore, early diagnosis and aggressive treatment, not only slow the disease's development, but also to some extent to improve the prognosis.
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