前列腺癌彩色血流信号平均密度(MCVD)与PSA相关性研究  

Correlation between mean color vessel density and prostate specific antigen in prostate cancer

作　　者：曹霞[1] 王薇[1] 郑春梅[1] 孙迎燕[2] 

机构地区：[1]佳木斯大学附属第一医院,黑龙江佳木斯154003 [2]牡丹江医学院红旗医院,黑龙江牡丹江157000

出　　处：《黑龙江医药科学》2010年第5期21-22,共2页Heilongjiang Medicine and Pharmacy

基　　金：黑龙江省卫生厅资助项目No:2004-010

摘　　要：目的:探讨彩色血流信号平均密度(MCVD)与前列腺特异性抗原(PSA)在无创诊断前列腺癌中的临床价值。方法:分析26例前列腺癌及对照组的声像图表现与PSA的测值,进行二维、彩色能量多谱勒检查,观察声像图特点,测量血流丰富区域收缩期峰值血流速度(PS)、舒张末期血流速度(ED)、阻力指数(R I)及搏动指数(P I),计算肿瘤组织及非肿瘤组织单位面积内彩色血流数,即肿瘤及非肿瘤的彩色血流信号平均密度(M CVD),并进行统计学分析。结果:26例前列腺癌中24例病灶在外腺,22例呈低回声结节,与对照组比较血流参数有显著差异(P<0.05),PSA及M CVD有显著差异(P<0.05),随分化程度降低,PSA及M CVD均增加,M CVD与PSA呈正相关(r=0.6826,P<0.01)。结论:M CVD能反映前列腺癌血管生成状况,经直肠超声为无创诊断前列腺癌最佳方法。Objective：To explore the clinical value of mean color vessel density（MCVD） and prostate specific antigen（PSA） in prostate cancer（PCA） by non-invasive diagnostic method.Methods：The echography features and the PSA level were analyzed in 26 cases of PCA and controls.They were examined by transcrectal ultrasound（TRUS） with two-dimensional echography（2DE） and Color Power Doppler（CPD）.The peak systolic velocity（PSV）,end-diastolic velocity（EDV）,resistive index（RI）and pulsative index（PI） were measured in rich blood flow signal region.Mean color vessel density（MCVD） was calculated. The data were analyzed statistically.Results：In the 26 cases of PCA,the lesions were located in prostatic outer gland in 24 cases and 22 cases showed a hypoechoic lesion,with significant differences in the parameters of hemodynamics between the two groups（P0.05）,and there was a significant difference between MCVD and PSA（P0.05）,and MCVD and PSA showed a positive rank correlation（r=0.501,P0.01）. Conclusion：MCVD can reflect the cancer neoangiogenesis in PCA,and TRUS is the best non-invasive diagnostic method in prostate cancer.

关 键 词：前列腺癌 经直肠超声 彩色血管能量多谱勒 彩色血流信号平均密度 前列腺特异性抗原 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.25[医药卫生—诊断学]