头部电针治疗抽动秽语综合征临床研究  

Clinical Effects and Influences of Neurotransmitters on the Treatment of GTS by Using Electroacupuncture on the Head

作　　者：刘丽[1] 李晓陵[1] 王丰[1] 许宇飞[1] 关昕[1] 

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中医药学报》2010年第5期128-131,共4页Acta Chinese Medicine and Pharmacology

基　　金：黑龙江省中医药管理局基金项目(项目编号:ZH04B13)

摘　　要：目的：探讨头部电针治疗抽动秽语综合征（GTS）的临床疗效及神经递质影响。方法：选择黑龙江中医药大学附属第一医院神经内科（针灸科）门诊就诊的确诊为GTS患儿60例。随机将其分为观察组和对照组各30例。观察组采用电针治疗,主穴：百会、风池、神庭、合谷、太冲、舞蹈震颤控制区。平补平泻法,在舞蹈震颤控制区和风池穴接通电针仪,选疏密波,刺激强度以患儿耐受为度。留针30m in,1次/d,20次为1疗程,共治疗3个疗程;对照组予以氟哌啶醇片2~8mg/d,分3次口服,并同时予等量的安坦以减少副反应,共连续用药2个月。分别于治疗前及治疗20d、40d、60d根据《耶鲁抽动症整体严重程度量表（YGTSS）》,按患儿抽动的类型、频率、强度、复杂性、对生活或行为影响程度五项进行评分。采用酶联免疫法测定治疗前后GTS患儿血浆多巴胺（DA）和血浆5-羟色胺（5-HT）。结果：头部电针疗法可以明显降低GTS患儿YGTSS评分,无论是运动抽动还是发声抽动及损伤因子三方面观察组与对照组比较差异有统计学意义（P〈0.05）;在临床疗效比较显示两组间无显著性差异（P〉0.05）,说明头部电针疗法治疗GTS疗效与目前公认的氟哌啶醇的疗效相媲美;头部电针可使GTS患儿血浆中的DA水平显著下降,血浆5-HT水平明显提高。结论：头部电针疗法可通过调节GTS患者血浆DA和5-HT发挥治疗作用,其疗效与目前公认的氟哌啶醇的疗效相当,值得推广使用。Objective： To explore the clinical effects and influences of neurotransmitters on the treatment of GTS by using electroacupuncture on the head.Method： choose 60 children diagnosed with GTS at the department of neurology（acupuncture） of the first hospital of Heilongjiang university of Traditional Chinese Medicine.Randomly divide into two groups each with 30 cases,one for observation and the other for comparison.Adopt electroacupuncture treatment to the group for observation.Main points：Baihui,Fengchi,Shenting,Heigu,Taichong,chorea tre-mor controlled area.Use moderate and equi-librious acupuncture technique,and connect to the electronic-acupression instrument at chorea tre-mor controlled area and Fengchi,select its dilatational wave and stimulating intensity according to tolerance limits of individual cases.30 minutes each time,one time per day,20 times every course of treatment,and three courses in total.Adopt the control group with oral tablets of haloperidol at the total daily amount of 8mg in three times per day and equal amount of artane to reduce side effects,constantly for two months.Record analyse and score on the type,frequency,intensity and complexity of twitch and its influence on the objects＇ life and behaviour according to the YGTSS respectively prior to the treatments and on the 20th,40th,and 60th days during the treatments.Adopt the method of enzyme-linked immunoassay to text the levels of DA and 5-HT in the plasma of each object prior to and after treatments.Result：using electroacupuncture on the head can dramaticly reduce the scores given by based on YGTSS.Statistical significance was found（P0.05） in twitch,chronic motive and damage factor between these two groups,while no statistical significance was found（P0.05） in clinical effect between them,representing that method of using electroacupuncture on the head is as effective as that commonly practiced of using haloperidol.Using electroacupuncture on the head can dramatically reduce the level of DA in the plasma of objects and

关 键 词：抽动秽语综合征 电针 头部腧穴 神经递质 

分 类 号：R245.9[医药卫生—针灸推拿学] R748[医药卫生—中医临床基础]