D-氨基葡萄糖Schiff碱的制备及抑制真菌性能研究  

Synthesis and antifungal activity of D-glucosamine Schiff base

作　　者：尹学琼[1] 黄建[1] 于长江[1] 刘芳[1] 林强[1] 

机构地区：[1]海南大学材料与化工学院热带生物资源教育部重点实验室,海南海口570228

出　　处：《化学试剂》2010年第11期961-964,共4页Chemical Reagents

基　　金：国家自然科学基金资助项目(50863002);海南省自然科学基金资助项目(20803);教育部热带生物资源重点实验室开放基金资助项目(HDZX08-64)

摘　　要：以D-氨基葡萄糖盐酸盐与对甲氧基苯甲醛、对甲基苯甲醛反应合成了两种新的D-氨基葡萄糖席夫碱(对甲氧基苯甲醛缩D-氨基葡萄糖席夫碱、对甲基苯甲醛缩D-氨基葡萄糖席夫碱),收率分别为67.9%、74.6%。使用UV1、HNMR和IR对产物进行了结构表征。测试了两种席夫碱甲醇饱和溶液对香蕉炭疽病菌、芒果炭疽病菌、芒果蒂腐病菌、芒果焦腐病菌、番木瓜炭疽病菌等植物病原真菌的抑菌性能。结果表明,对甲氧基苯甲醛缩D-氨基葡萄糖席夫碱对香蕉炭疽病菌、芒果蒂腐病菌、芒果焦腐病菌具有很强的抑菌活性,对甲基苯甲醛缩D-氨基葡萄糖席夫碱对香蕉炭疽病菌、芒果炭疽病菌具有很强的抑菌活性。Two D-glucosamine Schiff bases were synthesized from neutralized D-glucosamine chloride,4-methoxybenzaldehyde,and 4-methylbenzaldehyde.The yields were 67.9% and 74.6%,respectively.The product structures were characterized by UV,1HNMR,and IR spectroscopy.Antifungal properties in saturated methanol solution against Colletotrichum musae,Colletotrichum gloeosporioides,Phomopsis mangiferae,Botryodiplodia theobromae,and Gloeosporium papaya P.Henn were measured.D-glucosamine chloride-4-methoxybenzaldehyde showed excellent activity against Calletrotrichum musae,Phomopsis mangiferae,and Botryodiplodia theobromae Pat.D-glucosamine chloride-4-methylbenzaldehyde demonstarted good activity against Calletrotrichum musae,and Colletotrichum gloeosporioides.

关 键 词：D-氨基葡萄糖 苯甲醛席夫碱 合成 表征 抗真菌活性 

分 类 号：O629.11[理学—有机化学]