氯冉酸荷移分光光度法测定酒石酸美托洛尔  

Spectrophotometric determination of metoprolol tartrate based on the charge transfer reaction with chloranilic acid

作　　者：于丽丽[1] 刘佳川[1] 穆伟[1] 李华侃[1] 

机构地区：[1]辽宁医学院化学教研室,辽宁锦州121001

出　　处：《化学试剂》2010年第11期1003-1005,共3页Chemical Reagents

摘　　要：研究了酒石酸美托洛尔与氯冉酸之间的荷移反应。确定了最佳的反应条件,建立了一种快速简便测定酒石酸美托洛尔的荷移分光光度法。实验表明,酒石酸美托洛尔与氯冉酸在乙醇介质中,室温条件下即可形成稳定的1∶1型荷移配合物,该配合物的最大吸收波长为528 nm,表观摩尔吸光系数ε为1.92×10^3L·mol^-1·cm^-1。酒石酸美托洛尔的浓度在10～360 mg/L范围内服从比尔定律,相关系数r=0.999 7。相对标准偏差为0.66%（n=6）,回收率为99.7%～102.4%。The charge transfer reaction between metoprolol tartrate and chloranilic acid was investigated by spectrophotometry.The experimental optimum conditions were established,and a simple and rapid method for determination of metoprolol tartrate had been developed.Results showed that the composition ratio of charge transfer complex was 1∶1 in ethanol solution at room temperature.The apparent molar absorptivity of complex was 1.92×10^3 L·mol^-1·cm^-1 at 528 nm.The Beer′s Law was obeyed in the range of 10～360 mg/L of metoprolol tartrate with a correlation coefficient of 0.999 7.The relative standard deviation was 0.66%（n=6）.The recovery was 99.7%～102.4%.

关 键 词：荷移反应 酒石酸美托洛尔 氯冉酸 分光光度法 

分 类 号：O657.32[理学—分析化学]