2-萘胺的一种简易制备方法  

A facile method for preparation of 2-naphthylamine

作　　者：王秋文[1] 张站斌[1] 自国甫 

机构地区：[1]北京师范大学化学学院,北京100875

出　　处：《化学试剂》2010年第11期1033-1034,1039,共3页Chemical Reagents

基　　金：国家自然科学基金资助项目(20972018);北京市重点学科基金资助项目(21074013)

摘　　要：报道了标题化合物的制备方法。该方法首先用2-萘乙酮与盐酸羟胺反应生成中间体2-萘乙酮肟,然后该中间体在多聚磷酸催化下发生Beckmann重排反应生成2-乙酰萘胺,最后通过盐酸脱去乙酰基得标题化合物。该制备方法具有合成过程操作方便、分离提纯程序简单、生产安全等优点,特别适合于常规实验室的制备。A convenient method for preparation of 2-naphthylamine has been described.Firstly,treatment of 2-acetonaphthone with hydroxylammonium chloride in the presence of sodium acetate gave the intermediate 2-acetonaphthone oxime.Then rearrangement of 2-acetonaphthone oxime in the presence of polyphosphoric acid afforded 2-acetamidonaphthalene.Finally deacetylation of 2-acetamidonaphthalene with concentrated hydrochloric acid in ethanol gave 2-naphthylamine.This method has many advantages such as the facilitated operation,easy isolation or purification of the product,and working safety,which are strongly suitable for preparation in a standard laboratory.

关 键 词：2-萘胺 制备 2-萘乙酮肟 重排 

分 类 号：O625[理学—有机化学]