N-(4-吡啶基)-2-羟基苯甲酰胺的合成工艺研究  

Research on an improved process for synthesis of 2-hydroxy-N-(pyridin-4-yl)benzamide

作　　者：邱楠楠[1] 黄金程 李晓军[1] 董永喜[1] 陈桂玲[1] 吴争荣[1] 贺殿[1] 

机构地区：[1]兰州大学药学院药物化学研究所,甘肃兰州730000

出　　处：《化学试剂》2010年第11期1045-1046,共2页Chemical Reagents

摘　　要：首次以水杨酸为原料,与4-氨基吡啶反应合成了标题化合物,实验考察了不同的反应条件对产品收率的影响,得出最佳反应条件为:7 mmol 4-氨基吡啶、8.4 mmol水杨酸酰氯、11 mL三乙胺,25℃反应18 h,产品收率为87.8%。本合成路线反应条件温和、工艺操作简便、容易控制。2-Hydroxy-N-（pyridin-4-yl）benzamide was synthesized from salicylic acid and 4-aminopyridine.The effects of different reaction conditions on product yield were investigated.The target compound could be obtained in 87.8% yield after heating the reaction mixture（composed of 7 mmol of 4-aminopyridine,8.4 mmol of salicylyl chloride,and 11 mL of triethylamine） at 25 ℃ for 18 h.It has been proved that 2-hydroxy-N-（pyridin-4-yl）benzamide can be synthesized in high yield under the catalytic action of triethylamine.The reaction conditions suitable for this synthetic route are mild,and the process operation is simple and easily controllable.

关 键 词：水杨酸 水杨酸酰氯 4-氨基吡啶 N-(4-吡啶基)-2-羟基苯甲酰胺 

分 类 号：TK730.2[交通运输工程—轮机工程]