镁对大鼠脊髓损伤的保护作用  

Magnesium protects against experimental spinal cord injury

作　　者：陈恒胜[1] 伍亚民[1] 廖维宏[1] 

机构地区：[1]第三军医大学第三附属医院野战外科

出　　处：《中国康复医学杂志》1999年第2期68-70,共3页Chinese Journal of Rehabilitation Medicine

摘　　要：目的：了解镁对脊髓损伤的作用。方法：采用Ａｌｅｎ打击法（５０ｇ／ｃｍ）造成大鼠脊髓中度损伤，伤后静脉注射ＭｇＣｌ２（１００ｕｍｏｌ／ｋｇ），观察其对脊髓血流量（ＳＣＢＦ）和脊髓诱发电位（ＳＥＰ）的影响。结果：发生脊髓损伤后１ｈ，ＳＣＢＦ开始显著下降，４～８ｈ进一步下降，持续至伤后２４ｈ。ＳＥＰ峰潜伏时呈进行性延长趋势。伤后即刻静脉注射ＭｇＣｌ２，可使伤后ＳＣＢＦ有所改善，ＳＣＢＦ开始显著下降的时间延长１ｈ，并在伤后即刻升高ＳＣＢＦ，超过伤前的１０％；减轻伤后ＳＥＰ峰潜伏时的延长程度。结论：镁对受损脊髓早期有一定的保护作用。Objective:To investigate the relationship between Mg 2+ and spinal cord injury(SCI). Method:The rat spinal cord was injured by Allen′s weight drop method(50g/cm) and the effect of MgCl 2 treatment on posttraumatic spinal cord blood flow(SCBF) and spinal cord evoked potential(SEP) were examined at an intravenous injection of 100umol/kg. Result:The SCBF decreased significantly at first hour after SCI and continued to fall in 24h post injury, the SEP′s peak latencies tended to be delayed progressively. After treated with MgCl 2,SCBF increased 10% at 10min post injury and delayed the duration of trauma required to produce decline of SCBF from 1h to 2h. Meanwhile, SEP′s peak latencies were ameliorated to various degrees. Conclusion:Mg 2+ may protect the injured spinal cord by delaying the decreased of SCBF. It can also enhance the neural conduction of the spinal cord.

关 键 词：镁 脊髓损伤 治疗 大鼠 

分 类 号：R651.205[医药卫生—外科学]