ART中自然流产后胚胎染色体异常的初步研究  

Fetal chromosome abnormalities in early spontaneous abortion in pregnancies assisted reproductive technology

作　　者：高瑞花[1] 陈雷宁[1] 倪郝[1] 全松[1] 

机构地区：[1]南方医科大学南方医院妇产科生殖医学中心

出　　处：《广东医学》2010年第19期2486-2488,共3页Guangdong Medical Journal

基　　金：国家自然科学基金资助项目(编号:30872769);南方医科大学南方医院新技术新项目基金(编号:2006002)

摘　　要：目的探讨辅助生殖技术(ART)中妊娠早期流产胚胎染色体异常的相关因素。方法选择行体外受精-胚胎移植(IVF-ET)或卵泡浆内单精子注射(ICSI-ET)后22例妊娠早期流产患者,根据流产者绒毛染色体检测结果分为异常染色体核型组(n=17)和正常染色体核型组(n=5);并以同期35例继续妊娠妇女作为对照组,应用logistic回归分析ART方案中可能影响胚胎染色体的因素。结果新鲜移植周期自然流产率为10.95%(91/831),胚胎染色体异常发生率为77.27%;异常染色体核型组年龄[(34.7±4.1)岁]高于继续妊娠组[(31.6±3.9)岁],差异有统计学意义(P<0.05);3组ART促排方案中多因素分析比较差异无统计学意义(P>0.05)。结论 ART后自然流产者胚胎染色体异常可能与年龄因素相关。Objective To explore the relationship between fetal chromosome abnormalities and assisted reproductive technology（ART）in early spontaneous abortion.Methods Twentytwo patients received IVF-ET or ICSI-ET suffered from early abortion were divided into two groups according to villus genetic detection：abnormal group（17 cases）and normal group（5 cases）.Thirty five patients obtained ART without complications were enrolled in control group.Logistic regression was performed on clinical data and fetal chromosome results.Results The overall spontaneous abortion rate and incidence of fetal chromosomal abnormalities were 10.95%（91/813）and 77.78%（17/22）,respectively.A significant difference in maternal age was observed between abnormal group（35.3±2.77 years）and control group（31.6±3.95 years）.No difference in other parameters was found.Conclusion Maternal age is a risk factor of fetal chromosome abnormality-related miscarriage in ART.

关 键 词：胚胎染色体异常 自然流产 辅助生殖技术 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]