导电聚合物修饰的柔性神经微电极的制备与界面性质  

Integration of conducting polymer with flexible thin film microelectrode arrays for improved neural interfaces

作　　者：张华[1,2] 朱壮晖[1,2] 吴蕾[1] 周洪波[1] 孙晓娜[1,2] 周亮[1,2] 李刚[1] 金庆辉[1] 赵建龙[1] 

机构地区：[1]中国科学院上海微系统与信息技术研究所,上海200050 [2]中国科学院研究生院,北京100039

出　　处：《功能材料与器件学报》2010年第5期457-464,共8页Journal of Functional Materials and Devices

基　　金：国家973计划(No.2005CB724305);国家自然科学基金(No.30900315;60906055);上海市自然科学基金(No.07ZR14134);中国科学院上海微系统与信息技术研究所青年创新基金(No.2008QNCX02)

摘　　要：本研究提供了一种简易、低成本的工艺和方法,进行神经微电极的性能改进,来改善神经电极/神经组织的界面特性。首先采用光敏型聚酰亚胺(Durimide 7510)作为微电极基质材料制备了一种柔性神经微电极;然后电化学合成导电聚合物聚噻吩PEDOT/LiClO4,进行神经微电极位点的表面修饰;最后测试和评价了神经微电极的表面形貌、电学性能及其生物相容性。结果表明导电聚合物粗糙的菜花状表面形貌提供了更大的界面表面积,因此电极阻抗降低到原来的1/20,微电极的电荷注入能力也增加了约100倍。细胞生物学实验也表明,导电聚合物修饰的柔性微电极上,细胞生长状态良好,与未修饰的柔性微电极下相比,粘附率与存活率均有明显改善,粘附率较修饰前增加了92.5%,存活率也由69.2%提高到85.4%。In this paper,a simple and low-cost method for improving the performance of the neural microelectrodes is reported.Firstly,a photosensitive polyimide（Durimide 7510） was chosen as substrate to fabricate implantable flexible microelectrodes instead of silicon-based neural microelectrodes.Then,an electrochemical polymerization of conducting polymer PEDOT/LiClO4 was performed to modify the surface of the microelectrode sites.The morphology,electrical properties and biocompatibility of the coated microelectrodes were also investigated.The results showed that,due to the rough and cauliflower-like surface of the modified microelectrode sites which provides a higher interfacial area,the impedance of the microelectrode decreased to the original 1/20（@ 1KHz） and the charge injection capacity increased by about 100-fold.Biological tests also demonstrated that the modification of the microelectrode improved the interfacial properties for cell attachment and proliferation.Cell adhesion rate was 92.5% higher than that on unmodified surface;and survival rate also increased from 69.2% to 85.4%.Furthermore,the flexible polyimide substrate also exhibited good biocompatibility.

关 键 词：柔性微电极 导电聚合物 表面修饰 生物相容性 

分 类 号：TQ316.6[化学工程—高聚物工业]