扩张型心肌病Th细胞亚群分析  

A study of Th cell subsets in patients with dilated cardiomyopathy

作　　者：王秋芬[1] 廖玉华[1] 龚非力[2] 毛焕元[1] 张金枝[1] 

机构地区：[1]同济医科大学心血管病研究所,武汉430022 [2]同济医科大学免疫学教研室

出　　处：《临床心血管病杂志》1999年第3期100-101,共2页Journal of Clinical Cardiology

基　　金：卫生部科学研究基金!资助课题 (96- 2 - 1 0 5

摘　　要：的 :探讨扩张型心肌病 (DCM)的体液免疫学发病机制。方法 :借助免疫荧光标记及流式细胞仪技术分析 2 4例 DCM患者和 1 8例正常人的 Th淋巴细胞亚型。结果 :DCM组 Th2 细胞在外周血淋巴细胞中占 (0 .42± 0 .2 6) % ,CD4 -CD3 0 +细胞占 (0 .41± 0 .37) % ;对照组 Th2 细胞占(0 .2 1± 0 .1 1 ) % ,CD4 -CD3 0 +细胞占 (0 .0 7± 0 .0 5) %。DCM组 Th2 细胞和 CD4 -CD3 0 +细胞比例均明显高于对照组 (P <0 .0 1 )。结论 :DCM患者外周血中 Th2 细胞和 CD4 -CD3 0 +细胞可能参与了DCM的发病机制。Objective:In order to Probe into the humoral immunopathogenesis of DCM. Method:Th lymphocyte subsets in 24 patients with DCM and 18 normal control subjects were examined with the immunofluorescence technique and flow cytometry. Result:The percentages of CD 4 +CD 30 +(Th 2) and CD 4 -CD 30 + lymphocyte in patients were ( 0.42 ± 0.26 )% and ( 0.41 ± 0.37 )% respectively; the percentages of Th 2 cells and CD 4 -CD 30 + cells in normal control subjects were ( 0.21 ± 0.11 )% and ( 0.07 ± 0.05 )% respectively. The percentages of Th 2 and CD 4 -CD 30 + lymphocyte in patients with DCM were significantly higher than those in controls, P< 0.01 .Conclusion:Th 2 and CD 4 -CD 30 + lymphocyte may be involved in the immunopathogenesis of DCM.

关 键 词：扩张型心肌病 TH细胞亚群 发病机制 

分 类 号：R542.202[医药卫生—心血管疾病]