比索洛尔治疗扩张型心肌病心力衰竭对压力感受器功能的影响  

Effects of Bisoprolol on baroreceptor in patients with heart failure secondary to dilated cardiomyopathy

作　　者：李隆贵[1] 杨生春[2] 

机构地区：[1]第三军医大学附属新桥医院心内科,重庆400037 [2]吉林通化解放军512医院

出　　处：《临床心血管病杂志》1999年第3期102-105,共4页Journal of Clinical Cardiology

摘　　要：目的 :探讨比索洛尔治疗心力衰竭时对对压力感受器功能的影响。方法 :以倾斜试验时心率和血压的反应结合超声心动图检测 ,观察 2 2例扩张型心肌病 ( DCM)患者应用比索洛尔治疗前后压力感受器功能与心功能的变化。结果 :DCM心力衰竭患者存在压力感受器功能异常。经比索洛尔治疗 3个月心功能明显改善 ,倾斜试验心率、血压的反应也有显著恢复。压力感受器功能的恢复早于心功能的改善。结论 :比索洛尔对Objective:To evaluate effects of selective Bisoprolol on baroreceptor in patients with heart failure secondary to dilated cardiomyopathy (DCM).Method:We observed heart rate and blood pressure responses to head up tilt, and echocardiography in 22 patients with heart failure secondary to DCM before and after treated with Bisoprolol for 3 months, in order to assess effects of the treatment on baroreceptor and heart function. Result:There were baroreceptive abnormalities in patients with heart failure secondary to DCM. After treatment with Bisoprolol for 3 months, the patients′heart function, and the reaction of heart rate and blood pressure to tilt improved significantly. The recovery of baroreceptive abnormalities was more early than that of heart function. Conclusion:Bisoprolol is effective on the recovery of baroreceptive abnormalities in patients with heart failure secondary to DCM.

关 键 词：心力衰竭 压力感受器 扩张型心肌病 比索洛尔 

分 类 号：R542.206[医药卫生—心血管疾病] R541.610.5[医药卫生—内科学]