小剂量尼尔雌醇对绝经后妇女脂蛋白(a)和血脂的调脂疗效  

Lipids regulaling effects of small dose nylestriol on lipoprotein(a) and lipids in postmenopausal woman

作　　者：张加芳[1] 杨玖玲[2] 周明珍[3] 张真路[2] 谢彬[1] 胡婉红 严翠玲[1] 徐符英 

机构地区：[1]大桥局汉阳铁路中心医院内科,武汉430050 [2]大桥局汉阳铁路中心医院检验科 [3]大桥局汉阳铁路中心医院妇产科

出　　处：《临床心血管病杂志》1999年第3期122-124,共3页Journal of Clinical Cardiology

摘　　要：目的 :观察小剂量、长效尼尔雌醇对绝经后妇女脂蛋白 (a)〔 Lp(a)〕和血脂的影响。方法 :选择绝经 2年以上的妇女 54例 ,随机分为治疗组和对照组。治疗组每月服尼尔雌醇 1次 ,每次 2mg。结果 :治疗组 3个月后 HDL- C、apo- AI明显升高 ,LDL- C降低 ,Lp(a)治疗半年后开始下降 ,治疗 9个月后与对照组相比有显著性差异 ,1年后降低仍较显著 ,TC、TG无明显改变。对照组前后无明显改变。结论 :尼尔雌醇副作用轻 ,同时减轻绝经期妇女的更年期综合征症状。对高 Lp(a)、高LDL- C或者低 HDL-Objective:To evaluate the lipids regulating effects of small dose nylestriol on lipoprotein(a) 〔Lp(a)〕 and lipids in postmenipause women.Method:54 cases of women who had menopause for more than 2 years were enrolled and randomly divided into 2 groups.Only 40 of them reached end points of 1 year observation.Group A(21 cases) received oral nylestriol 2 mg once monthly.Group B (19 cases) received placebo as control.Result:HDL C、apo AI increased after 3 months and LDL C decreased.The Lp(a) began to decrease after half a year.There were remarkable differences between two groups after 9 months and differences still existed after a year.TC and TG didn't change greatly.Conclusion:Hormone replacement therapy can decreases Lp(a) and LDL C levels,while increase HDL C levels.This effect may be one of the mechanisms of the cardioprotective effects of estrogen.Nylestriol has mild side effects and relieve the syndrome of postmenopausal.So it can be used as the first single drug to prevent women with high Lp(a)、high LDL C or low HDL C level from coronary heart disease.

关 键 词：脂蛋白(a) 血脂 尼尔雌醇 绝经后 调脂 

分 类 号：R588.05[医药卫生—内分泌]