硒对高胆固醇血症家兔血液流变性的影响  

Effects of Selenium on Hemorheological Property in Rabbits with Hypercholestorolaemia

作　　者：李爱阳[1,2] 王茜[1,2] 谈兵[1,2] 周方钧[1,2] 

机构地区：[1]中国人民解放军第208医院 [2]白求恩医科大学附属中日联谊医院心内科

出　　处：《微量元素与健康研究》1999年第1期10-12,共3页Studies of Trace Elements and Health

摘　　要：对高胆固醇血症家兔应用硒（Ｓｅ）后血液流变性、过氧化脂质（ＬＰＯ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）和超氧化物歧化酶（ＳＯＤ）、血栓素（ＴＸＡ２）、前列环素（ＰＧＩ２）进行观察。发现Ｓｅ可不同程度降低高胆固醇家兔红细胞压积和红细胞聚集性，增加红细胞变形性，降低血清ＬＰＯ含量、ＴＸＡ２／ＰＧＩ２比值和ＴＸＡ２水平，提高ＧＳＨ－Ｐｘ、ＳＯＤ活力和ＰＧＩ２水平。Changes of hemorheological properth,lipid peroxides(LPO)levels,glutathion peroxidase (GSH-Px) and superoxide dismutase (SOD) activities in rabbits with hypercholesterolaemia were observed by using selenium (Se).The results showed that hemotocrit and erthrocyte aggregation were reduced ,and erythrocyte deformability was increased in rabbits on Se.Simultaneously,concentration of LPO,level of TXA 2 were reduced,activities of GSH-Px and SOD,level of PGI 2 were significantly enhanced.The study suggested that Se have a decreased effect on blood viscosity.

关 键 词：硒 高胆固醇血症 血液流变学 家兔 

分 类 号：R589.202[医药卫生—内分泌]