α-硫辛酸在糖尿病治疗中的临床应用价值  

Clinical value of alpha-lipoic acid in the management of diabetes mellitus

作　　者：王俐[1] 蔡美琴[1] 

机构地区：[1]上海交通大学医学院营养系,200025

出　　处：《中华临床营养杂志》2010年第5期323-326,共4页Chinese Journal of Clinical Nutrition

摘　　要：氧化应激是糖尿病发病的重要机制，α-硫辛酸作为一种强抗氧化剂，能清除自由基，减轻氧化损伤，目前已广泛应用于糖尿病并发症的临床治疗。本文主要综述α-硫辛酸在减轻糖尿病患者的氧化应激损伤、保护糖尿病患者的血管病变、治疗糖尿病的多发性神经症状、调节胰岛素敏感性等方面的作用。Oxidative stress plays an important role in the progression of diabetes mellitus. As a potent antioxidant, alpha-lipoic acid is able to clear free radicals and alleviate oxidative damages and therefore has been widely applied in the clinical management of diabetes mellitus. This article summarizes the clinical application of alpha-lipoie acid in alleviating diabetes mellitus-related oxidative damages, protecting vascular lesions, treating diabetic polyneuropathies, and modulating insulin sensitivity.

关 键 词：Α-硫辛酸 氧化应激 糖尿病 并发症 临床应用 

分 类 号：R587.2[医药卫生—内分泌]