小儿肾病综合征的中长期随访研究  

Prognosis of nephrotic syndrome in children:a medium and long-term follow-up

作　　者：谢祥鳌[1] 马恒颢[1] 王丹[1] 刘颖[1] 

机构地区：[1]广州军区广州总医院儿科

出　　处：《中国实用儿科杂志》1999年第3期152-154,共3页Chinese Journal of Practical Pediatrics

摘　　要：目的探讨小儿肾病综合征（ＮＳ）的预后及有关因素。方法对７２例小儿ＮＳ患儿作中、长期随访，其中１６例随访１０年，４９例随访５年，７２例随访３年。结果３组的完全缓解率分别为７５％、８４％及７９％。基本痊愈率在５年组为４９％，１０年组为６９％。死亡３例。结论肾小球的组织学改变与预后有关。小儿ＮＳ总的预后较好；微小病变、膜性肾病的预后较局灶硬化、弥漫性硬化及膜增殖型要好；轻、中度系膜增殖型预后好，严重增殖者预后较差。延长激素疗程，缓慢停药可增加缓解率。Objective To identify the prognosis of nephrotic syndrome(NS) and its relative factors.Methods 72 children with NS were followed up.Among them, 16 cases were followed for 10 years(10 yrs group),49 cases for 5 years(5yrs group) and 72 cases for 3 years(3yrs group).Results The complete remisson rate of these three groups was 75%,84% and 79%,respectively;while the clinic cure rate-keeping in remission for more than 3 years without corticosteroid treatment was 69% in 10 yrs group and 49% in 5 yrs group.Three of 72 children died.Conclusion There was a close correlation of remission and cure rate with glomerular histological features.The prognosis is better in minimal change disease and membranous nephropathy than in focal segmental glomerulosclerosis,diffuse glomerulosclerosis and membrano-proliferative glomerulonephritis.In the mesengial proliferation,the light or moderate ones has favorable prognosis,but is not the case in severe ones.Additionally,a long course and slowed withdraw of corticosteroid would be beneficial to increase remission cases and diminish the frequency of relaps.

关 键 词：肾病综合征 随访 预后 儿童 

分 类 号：R726.92[医药卫生—儿科]