急性有机磷中毒患者纤溶功能动态变化特点及长托宁干预效果研究  

Dynamic Changes of Fibrinolytic Function in Patients with Acute Organophorus Pesticides Poisoning and Clinical Interventional Effects of Penehyclidine Hydrochloride

作　　者：朱海明[1] 郑美英[1] 王庭学 王龙 黄晓辉[3] 王光余[3] 李红珊[3] 吴国平[3] 

机构地区：[1]海南省农垦总医院药剂科,海南省海口市570311 [2]琼海市人民医院急诊科 [3]海南医学院附属医院急诊教研室

出　　处：《中国全科医学》2010年第31期3567-3569,共3页Chinese General Practice

摘　　要：目的探讨急性有机磷中毒患者(AOPP)纤溶功能动态变化特点及长托宁的干预效果观察。方法对我院34例AOPP患者采用长托宁治疗,分析了入院第1、3、5、7、9天患者各种纤溶指标的动态变化趋势。结果不同中毒程度AOPP患者纤溶指标检测结果差异均有统计学意义(P<0.05),以重度中毒患者的纤溶指标最低。对有无并发症的AOPP患者分析显示:两者各种纤溶指标检测结果差异均有统计学意义(P<0.05)。长托宁治疗前后AOPP患者纤溶指标检测结果差异均有统计学意义(P<0.05)。结论 AOPP能够影响患者的纤溶功能,同时不同中毒程度以及并发症的有无对各种纤溶指标有明显的影响,采取长托宁治疗能够明显改善AOPP患者的纤溶功能。Objective To study the feature of dynamic changes of fibrinolytic function in patients with acute organophorus pesticides poisoning （AOPP） and clinical interventional effects of penehyclidine hydrochloride.Methods Totally 34 AOPP patients were given the therapy of penehyclidine hydrochloride,and the trend of dynamic changes of fibrinolytic indexes in the first,third,fifth,seventh and ninth day after admission was analyzed.Results The statistical significance was found in fibrinolytic indexes among AOPP patients with different degreed poisoning （P〈0.05）,and the values of fibrinolytic indexes were lowest in patients with severe poisoning.The statistical significance was found in fibrinolytic indexes between AOPP patients with and without complications （P〈0.05）.The statistical significance was found in fibrinolytic indexes of AOPP patients after the therapy of penehyclidine hydrochloride （P〈0.05）.Conclusion AOPP can affect on the fibrinolytic function of AOPP patients,and the degree of poisoning and complications can obviously impact the fibrinolytic indexes.The therapy of penehyclidine hydrochloride can significantly improve the fibrinolytic function for AOPP patients.

关 键 词：急性有机磷中毒 纤溶指标 动态变化 长托宁 

分 类 号：R595.51[医药卫生—内科学]