经皮使用苯甲酸雌二醇凝胶治疗更年期综合症临床研究  

CLINICAL STUDY OF TREATMENT OF CLIMACTERIC SYMPTOMS WITH PERCUTANEOUS ESTRADIAL BENZOATE GEL

作　　者：杨欣[1] 白文佩[1] 郑淑蓉[1] 李辉 

机构地区：[1]北京医科大学第一临床医学院妇产科

出　　处：《中国临床药理学杂志》1999年第2期105-105,共1页The Chinese Journal of Clinical Pharmacology

摘　　要：为了评估经皮使用苯甲酸雌二醇凝胶加口服安宫黄体酮周期序贯应用治疗更年期综合症的疗效和安全性，５４例更年期综合症患者按２：１比例接受苯甲酸雌二醇或１７β－雌二醇凝胶治疗共４个周期，观察比较两药的临床疗效、生化指标、激素测定、子宫内膜厚度、阴道出血及其他药物不良反应。结果表明苯甲酸雌二醇及１７β－雌二醇凝胶治疗更年期综合症均能有效的缓解潮热出汗等更年期症状，用药４个月ｋｕｐｐｅｒｍａｎ总分分别下降８６．０％及８３．０％。主要药物不良反应为与孕激素联合使用阴道出血率较高，且前者用药有轻度的皮肤反应。两药对肝肾功能、血脂子宫内膜厚度无明显影响。结论为苯甲酸雌二醇凝胶治疗更年期疗效显著。To know the effects of percutaneous estradiol benzoate gels on menopausal symptoms and their safety, 54 symptomatic postmenopausal women received either estradiol benzoate gel (n=36) or 17β-estradiol gel (oestrogel) (n=18) for the 24 first days of each month during four consecutive months. Medroxyprogesterone acetate (MPA) was administered orally from day 15～24 of each month .The menopausal symptoms , endometrial thickness, incidence of vaginal bleeding,and lab test were evaluated before and at end of therapy. Our results showed that menopausal symptoms were relieved significantly by estradiol benzoate and 17β-estradiol gel , Kupperman score decreased 86.0% and 83.0%. The side effect was mainly bleeding. Some women with estradiol benzoate gel had skin reaction. The conclusion is that estradiol benzoate gel can relieve menopausal symptoms effectively. The cyclic sequential therapy of gel and MPA is safe.

关 键 词：更年期综合症 激素疗法 苯甲酸雌二醇 凝胶 

分 类 号：R588.05[医药卫生—内分泌] R977.12[医药卫生—内科学]