胆道感染患者的致病菌分布及药敏试验的临床研究  

作　　者：魏斌[1] 杨志伟[1] 胡宇伟[1] 杨朝霞[1] 汤聪[1] 

机构地区：[1]广东省中山大学附属第五医院普外四科微创外科中心,519000

出　　处：《医学信息（下旬刊）》2010年第11期104-105,共2页Medical information

基　　金：本研究为珠海市医学科研计划资助项目（项目编号0067 6384 7942 1088）

摘　　要：目的：研究我院近4年胆道感染患者的致病菌分布及其药物敏感性,为临床合理用药提供依据.方法：对2007年1月～2010年8月我院收治的287例胆道感染患者胆汁培养的病原菌分布和药敏情况进行统计分析. 结果：287例患者胆汁标本中分离培养出194株细菌, 阳性率67.6%;革兰阴性杆菌126株（64.95%）,主要为大肠埃希菌68株（35.05%）、肺炎克雷伯菌26株（13.4%）、铜绿假单胞菌14株（7.22%）等;革兰阳性球菌57株（29.38%）,依次为肠球菌30株（15.46%）、葡萄球菌属16株（8.25%）、链球菌5株（2.58%）等;真菌11株（5.67%）.革兰阴性杆菌敏感率最高的是亚胺培南;革兰阳性球菌的敏感率最高的是万古霉素.真菌对二性霉素敏感率最高.结论：胆道感染病原体仍以革兰阴性杆菌为主.但革兰阳性球茵、真菌也占有一定比例.根据胆汁培养及药敏结果,合理应用抗生素是治疗胆道感染的关键.Objective：To study the bacteria distribution and drug susceptibility of biliary infection in our hospital during last 4 years, provide the basis for the clinical use of drugs. Methods：287 patients in our hospital biliary tract infection and bacterial culture of bile sensitivity were statistically analyzed , during Jan 2007 and Aug 2010. Results ： Bile samples of 287 patients were isolated and cultured 194 bacteria , the positive rate of 67.6%, Gram-negative bacteria 126 （64.95%）, mainly EscherichiaColi（68,35.05%）, KlebsicllaPneumoniac（26,13.4%）, PseudomonasAeruginosa （14, 7.22%）, etc. Grampositive cocci（57,29.38%）, followed by Enterococci（30,15.46%）, Staphylococcus（16,8.25 %）, Streptococcus（5,2. 58%）, etc. , 11 strains of fungus were tested and occupied 5.67% . Gram-negative bacteria are sensitive to the highest rate of Imipencm; sensitive gram-positive cocci is the highest rate of Vancomycin. Sensitive fungi to Amphotericin highest rate. Conclusions-Biliary tract infection pathogens is still the main gram-negative bacilli. However, gram-positive ball-yan,a certain proportion of fungi. According to the results of bile culture and drug susceptibility, rational use of antibiotics is the key to treatment of biliary tract infection.

关 键 词：胆道感染 致病菌分布 药敏试验 

分 类 号：R657.4[医药卫生—外科学]