亚胺培南-西司他丁钠致老年患者痫性发作  

Imipenem/cilastatin sodium-induced epileptic seizure in an elderly patient

作　　者：乔薇[1] 李一鸣[2] 沈玲美[1] 张小平[1] 

机构地区：[1]中日友好医院干部保健病房,北京100029 [2]中日友好医院呼吸内科,北京100029

出　　处：《药物不良反应杂志》2010年第5期353-354,共2页Adverse Drug Reactions Journal

摘　　要：1例100岁男性患者,因肺炎给予亚胺培南-西司他丁钠0.5g加入0.9%氯化钠注射液100mL静脉滴注,1次/12h。第2次输注完毕2h后患者突然出现意识不清、双眼向上凝视、牙关紧闭、口唇发绀,HR126次/min,BP178/86mmHg,血氧饱和度80%。立即给予对症支持治疗,约4min后症状缓解。停用亚胺培南-西司他丁钠,改为美罗培南,10d后肺炎治愈。此后未再应用亚胺培南-西司他丁钠,未再出现痫性发作。A 100-year-old male patient with pneumonia received an IV infusion of imipenem/cilastatin sodium 0.5 g in 0.9% sodium chloride 100 mL every 12 hours.Two hours after the second infusion completion,the patient suddenly presented with confusion,upward gaze,trismus,and cyanosis.His heart rate was 126 beats/min,blood pressure was 178/86 mm Hg,and oxygen saturation was 80%.Supportive and symptomatic treatment was given immediately and,about four minutes later,the symptoms improved.Imipenem/cilastatin sodium was withdrawn and changed to meropenem.Ten days later,his pneumonia was cured.Imipenem/cilastatin sodium were not given again and epileptic seizure did not recur anymore.

关 键 词：亚胺培南-西司他丁钠 不良反应 痫性发作 

分 类 号：R978.11[医药卫生—药品]