多波长线性回归法同时测定安痛定注射液中的三组分  

Simultaneous determination three components in injection antongding by improved multiwavelength linear regression utraviolet spectrophotometry

作　　者：周明达[1] 喻晓峰 彭爱芝 周平[2] 夏令伟[2] 

机构地区：[1]湖南医科大学基础医学院 [2]湖南医科大学分析测试中心

出　　处：《中国医院药学杂志》1999年第4期205-206,共2页Chinese Journal of Hospital Pharmacy

摘　　要：目的：对安痛定注射液中的三组分实行分光光度法同时测定。方法：对传统的多波长线性回归分光光度法进行改进，使其不需要等吸收波长。结果：９份模拟样品中氨基比林、安替比林、巴比妥的平均回收率分别为９９．９％、９９．８％、１００．３％，相对标准偏差分别为０．５％、１．０％、１．７％。对３个批号实际样品的测定结果与标准方法一致。结论：方法简便快捷，适于安痛定注射液的制剂分析。OBJECTIVE:To study simultaneous spectrophotometric determination of three components in injection antongding.METHODS:An improved multiwavelength linear regression spectrophotometry was proposed.This method did not need the equal absorbance wavelengths.RESULTS:The average recoveries of aminopyrine,antipyrine and barbital in synthetic samples were 99.9 %、 99.8 % and 100.3 %,the relative standard deviations for them were 0.5 %, 1.0 %and 1.7 % respectively( n =9).The results of determination for three batches of actual samples were agreed with those by standard method.CONCLUSIONS:This method is simple,rapid, and suitable for analysis in injection antongding.

关 键 词：多波长线性回归 安痛定注射液 氨基比林 

分 类 号：R971.1[医药卫生—药品] R927.2[医药卫生—药学]