精氨酸促进低分子肝素口服吸收的研究  

Study of Enhancing Effect of Arginine on Oral Absorption of LMWH

作　　者：王书侠[1] 张振海[1] 张家明[1] 吕慧侠[2] 葛高霞[3] 

机构地区：[1]江苏省中医药研究院,南京市210028 [2]中国药科大学 [3]南京医科大学第一附属医院

出　　处：《职业与健康》2010年第22期2568-2570,共3页Occupation and Health

摘　　要：目的低分子肝素是一种有效的溶栓剂,目前只有注射剂用于临床,该实验研究精氨酸对低分子肝素口服吸收的促进作用。方法以大鼠用药前后血液凝固时间的变化研究精氨酸的肠道促吸收作用。结果精氨酸能够显著延长大鼠的凝血时间。在精氨酸与低分子肝素摩尔比为30∶1时,低分子肝素的药效学生物利用度达到11.7%。结论精氨酸能够显著促进低分子肝素的肠道吸收。[Objective]Low Molecular Weight Heparin （ LMWH） is a effective thrombolytics which is used to clinics merely for its injection at present. This experiment studies enhancing effect of arginine on oral absorption of LMWH. [Methods]The oral absorption enhancing effect of arginine on LMWH was determined by the change of rat blood coagulation time before and after administration.[Results]Blood coagulation time was significantly prolonged after intraduodenal administration of LMWH to rats. When molar ratio of arginine to LMWH was 30∶ 1,pharmacological bioavailability of LMWH was 11. 7% .[Conclusion]Arginine can obviously promote intestinal absorption of LMWH.

关 键 词：精氨酸 低分子肝素 口服 

分 类 号：R114[医药卫生—卫生毒理学]