连云港市艾滋病患者及感染者血液中CD4监测动态分析  

Dynamic Analysis on CD4 Surveillance? of ADIS Patients and HIV Infectors in Lianyungang City

作　　者：乙永林[1] 王炳留[1] 

机构地区：[1]江苏省连云港市疾病预防控制中心,222003

出　　处：《职业与健康》2010年第22期2645-2647,共3页Occupation and Health

摘　　要：目的通过动态分析,了解和掌握艾滋病(AIDS)患者和艾滋病病毒(HIV)感染者血液中CD4变化趋势和规律特点,为是否给予CD4检测提供科学依据。方法 CD4检测用单平台一步法,数据用统计学方法处理。结果 HIV感染者大多数CD4逐步下降,治疗后开始回升,治疗3个月后速度最快,与治疗月相比,差异有统计学意义(P<0.01)。其后速度减缓,差别不显著。在未治疗者中,有28.1%的患者CD4低于200个/μ1。监测期间的死亡者,多为本人未及时接受救治所致。结论 HIV-1抗体阳性确认后,治疗前和用新方案治疗3个月,出现临床危相者都应列入CD4监测对象。检测工作安排定期检测和应急检测较为完满。CD4检测设到地方级实验室更有利于工作。[Objective]To master the blood CD4 variation tendency and variation tendency characteristics of AIDS patients and HIV infectors through dynamic analysis,and provide scientific evidence for whether given CD4 testing or not. [Methods]Mono-platform method was adopted to conduct CD4 test,and the data were statistically analyzed.[Results]CD4 levels of most HIV infectors decreased gradually,but upgrade quickly after treatment,then reached the peak speed 3 months after treatment,comparing with the treatment month,the difference was significant（ P 0. 01） . After that the upgrade speed slowed down,but the difference was not significant. Of patients without treatment,CD4 levels of 28. 1% was less than 200 /μ1. Most of the death cases were due to untimely treatment.[Conclusion]After the confirmed HIV-1 antibody positive,patients with manifestation of clinical risk should be recruited as CD4 monitoring object,before treatment and 3 months after new treatment. The perfect CD4 test should include periodic and emergency tests. And it is convenient to put the CD4 test in municipal laboratory.

关 键 词：AIDS患者 HIV感染者 CD4 动态分析 

分 类 号：R181.3[医药卫生—流行病学]