氧化抗氧化与慢性乙型病毒性肝炎相关性研究  

Study on Correlation between Oxidation-antioxidation and Chronic Hepatitis Viral B

作　　者：孟连柱 高爱武[2] 边剑飞[3] 韩丽娟[2] 陈晖[1] 

机构地区：[1]河北省保定市传染病医院,071000 [2]保定市第二医院 [3]河北大学附属医院

出　　处：《职业与健康》2010年第23期2889-2890,共2页Occupation and Health

摘　　要：目的探讨慢性乙型病毒性肝炎(chronic viral hepatitisB)(慢乙肝)患者血清锰超氧化物歧化酶(manganese superoxide dismutase,MnSOD)和硝基酪氨酸(nitrotyrosine,NT)水平的变化。方法选择慢乙肝患者40例,健康对照组20例,应用酶联免疫吸附试验检测血清NT水平,黄嘌呤氧化酶法检测血清MnSOD水平。结果慢性乙型病毒性肝炎患者与对照组相比,NT浓度升高,MnSOD浓度降低(P<0.05)。差异有统计学意义。结论慢性乙型病毒性肝炎患者存在NT、MnSOD水平的变化,说明慢性乙型病毒性肝炎患者体内存在氧化抗氧化反应,有氧化应激的发生。[Objective] To study the changes of serum manganese superoxide dismutase （MnSOD） and serum nitrotyrosine （NT） in patients with chronic viral hepatitis B.[Methods]40 patients with chronic viral hepatitis B and 20 health subjects were selected. The serum NT level was tested by ELISA,and the serum MnSOD level was tested by Xanthinoxidase method.[Results]Compared with the control group,the NT level of the chronic viral hepatitis B group increased,the MnSOD level decreased,and the differences were significant （P〈0.05）.[Conclusion]The changes of NT and MnSOD level in patients with chronic viral hepatitis B indicated there existed oxidation-antioxidation response and oxidative stress in patients.

关 键 词：慢性乙型病毒性肝炎 硝基酪氨酸 锰超氧化物歧化酶 氧化应激 

分 类 号：R446.1[医药卫生—诊断学]