经血宁胶囊醇提物凝血作用的比较研究  

Comparative Study on Coagulating Action of Water Extract and Alcohol Extract of Jingxuening Capsule

作　　者：方显明[1] 谢金鲜[1] 韩邦志[1] 霍宇[1] 

机构地区：[1]广西中医学院,南宁530001

出　　处：《中国实验方剂学杂志》2010年第16期140-142,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技支撑计划子课题(2006BAI06A18-14)

摘　　要：目的:研究和比较经血宁胶囊醇提物及水提物的凝血作用。方法:动物随机分成6组,即经血宁醇提物3个剂量组(生药18,9.0,4.5 g·kg-1),经血宁水提物组,云南白药组及空白对照组。测定各组凝血时间(CT),凝血酶时间(TT),凝血酶元时间(PT),活化部分凝血活酶时间(APTT),纤维蛋白原(Fbg),血小板(PLT)等凝血指标。结果:与空白对照组比较,经血宁醇提物能明显缩短CT,TT,PT,APTT,血浆复钙时间(PRT),增加Fbg含量和PLT数量(P<O.05或P<0.01)。与经血宁水提物比较,经血宁醇提物缩短TT,APTT,PRT的作用优于后者(均P<0.05)。结论:经血宁醇提物具有显著的凝血作用,其作用强于经血宁水提物。Objective：To study the coagulating action of both extracts（alcohol extract and water extract）of Jingxuening Capsule（JXNC） to find the differences between them.Method： Laboratory animals were randomly divided into six groups,namely blank control group,Yunnan Baiyao powder（YBP） group,JXNC1（extracted by water）and three dosages groups（containing crude drug 18,9.0,4.5 g.kg-1 respectively） of JXNC2（extracted by alcohol）.CT,TT,PTT,APTT,Fbg,PLT and PRT of each group were tested after administration by ig for 5 or 6 days.Result：Compared with blank control group,JXNC 2 groups were able to shorten CT,TT,PT,APTT,PRT,and increase the content of Fbg and PLT significantly.Compared with JXNC 1 group,TT,APTT,PRT of JXNC 2 were shorter than that of the former（P 〈 0.05）.Conclusion： JXNC 2（alcobol extract） has good action for blood coagulation,and it is better than JXNC 1（water extract）.

关 键 词：经血宁胶囊 凝血作用 醇提物 水提物 

分 类 号：R285.5[医药卫生—中药学]