白花前胡蜜炙前后的药效学比较研究  

Comparative Studies on Pharmacological Effects for Processed Pieces from Peucedanum praeruptorum

作　　者：张村[1] 殷小杰[1] 李丽[1] 李文[1] 肖永庆[1] 于定荣[1] 麻印莲[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2010年第15期146-148,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"十一五"科技支撑计划(2006BAI09B06-08-02);国家科技重大专项项目(2009ZX09301-005-03)

摘　　要：目的:比较白花前胡蜜炙前后润肺止咳作用的药效学差异。方法:以小鼠气管酚红祛痰法、氨水喷雾致咳法、豚鼠磷酸组胺喷雾致喘法,观察前胡蜜炙前后的祛痰、镇咳和平喘作用的差异。结果:祛痰作用以蜜前胡中剂量最强,蜜前胡高剂量镇咳效果较佳,平喘作用以蜜前胡低剂量和生前胡低剂量明显。结论:前胡蜜炙后祛痰、平喘、止咳作用较生品略有增强,初步揭示了前胡蜜炙后润肺、化痰、止咳作用增强的炮制原理。Objective： To compare the pharmacological effects of Peucedanum praeruptorum before and after honey roasted pieces.Method： The pharmacological experiments for expectorant,antitussive and relieving asthma effects were tested by means of mouse tracheas excretion contents of phenol red,cough induced by ammonia water and the guinea pig model induced by histamine phosphate accordingly.Result： The middle and large-dosage of the honey roasted products showed the strong expectorant and antitussive effects while the small-dose of honeyed pieces and the raw pieces exhibited the better relieving action for asthma.Conclusion： The honey roasted pieces have slightly better efficiency than the raw pieces.It primarily elucidates the processing principle of the stir-baking with honey for P.praeruptorum.

关 键 词：白花前胡 蜜炙 药理作用 

分 类 号：R285.5[医药卫生—中药学]