离体外翻肠囊法研究丹参水溶性提取物丹酚酸B的大鼠肠吸收特性  

Rat Intestine Absorption Characteristics for Salvianolic Acid B with Isolated Everted Intestine Model

作　　者：张英丰[2] 杨庆[1] 李玉洁[1] 董宇[3] 翁小刚[1] 朱晓新[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]广州中医药大学,广州510006 [3]中国中医科学院广安门医院,北京100053

出　　处：《中国实验方剂学杂志》2010年第15期187-191,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科学自然基金重点项目(30930114);国家自然科学基金项目(30701097);国家“十一五”科技支撑计划课题(2006BAI08B04-4);中国博士后基金资助项目(20070420509)

摘　　要：目的:考察丹酚酸B的肠吸收特性。方法:采用离体外翻肠囊法考察丹参水溶性提取物丹酚酸B在不同肠段的肠吸收特性,采用HPLC-UVD测定样品浓度,计算肠吸收速率常数(Ka)。结果:随着药液中丹酚酸B浓度上升,肠吸收速率常数呈线性增加;各个肠段的吸收速率均无显著性差异。结论:丹酚酸B在小肠内不存在特殊的"吸收窗",在小肠中为被动扩散吸收。Objective： To study the intestine absorption of salvianolic acid B.Method： The isolated everted intestine model was used to study the absorption in different regions of rat intestine（duodenum,jejunum,ileum and colon）.The sample was determined with HPLC in combination with ultraviolet detector.Result： The intestine absorption rate constant increased along with the increase in concentration of salvianolic acid B.The absorption rate had no significant difference between different regions of the intestine.Conclusion： The absorption of salvianolic acid B by intestine appears to be a passive diffusion process and it does not contain a special absorption window..

关 键 词：丹酚酸B 肠吸收 离体外翻肠囊法 

分 类 号：R285.5[医药卫生—中药学]