一贯煎多糖对小鼠肝损伤及SOD,LPO的影响  

Effects of Yiguanjian polysaccharides on liver injury and SOD and LPO in the body of mice

作　　者：陈永祥[1] 王和生[1] 靳凤云[1] 巫霞[1] 吴家红[1] 冯英[1] 

机构地区：[1]贵阳中医学院

出　　处：《中国药学杂志》1999年第4期239-241,共3页Chinese Pharmaceutical Journal

摘　　要：目的：研究一贯煎提取的多糖对小鼠实验性肝损伤的保护及体内超氧化物歧化酶（ＳＯＤ）、过氧化脂质（ＬＰＯ）的影响。方法：采用四氯化碳（ＣＣｌ４）致小鼠肝损伤，测定生化指标，观察病理组织学改变，检测小鼠ｉｇ多糖后体内ＳＯＤ活性和ＬＰＯ含量，与对照组进行比较。结果：一贯煎多糖明显降低ＣＣｌ４引起的小鼠血清丙氨酸转移酶（ＡＬＴ）升高，减轻肝细胞的变性坏死，升高小鼠体内ＳＯＤ活性，减少ＬＰＯ含量。结论：一贯煎多糖与其煎剂有类同作用，揭示多糖可能是药效学成分之一，为临床用方治病提供实验依据。OBJECTIVE:To investigate the protective effects of refined polysaccharides from Yiguanjian on experimental hepatic injury,SOD activity,LPO concentration in mice.METHODS:Injury the livers of mice by using CCl 4,determine its biochemical index,observe the change of pathological histology,test the activity of SOD and content of LPO in the mice after polysaccharides ig,and compare with normal animals.RESULTS:Yiguangjian polysaccharides can decrease obviously the increase of ALT in mice caused by CCl 4,reduce the denaturation and necrosis of liver cells,increase SOD activities in the body of mice,and reduce the content of LPO.Oral polysaccharides is safe.CONCLUSION:Yiguangjian polysaccharides and Yiguangjian decoction have a similar function,which shows that polysaccharides refined from Yiguanjian may be one important pharmacodynamic constituent and provides an experimental basis for clinical practice.

关 键 词：一贯煎多糖 实验性 肝损伤 SOD LPO 

分 类 号：R259.75[医药卫生—中西医结合]