慢性肾脏病患者血清骨保护素甲状旁腺激素与骨密度的关系  

Serum osteoprotegerin and parathyroid hormone levels are associated with the lumbar bone mineral density in chronic kidney disease

作　　者：陈高翔[1] 张烽[2] 黄德芳[3] 张松[3] 须梅[4] 杜渊[1] 李春庆[1] 

机构地区：[1]江苏省无锡市第三人民医院肾内科,江苏无锡214041 [2]江苏省无锡市第三人民医院检验科,江苏无锡214041 [3]江苏省无锡市第三人民医院内分泌科,江苏无锡214041 [4]江苏省无锡市第三人民医院骨密度室,江苏无锡214041

出　　处：《中国现代医学杂志》2010年第20期3164-3166,共3页China Journal of Modern Medicine

基　　金：江苏省无锡市科技局资助项目(No:CS0550006)

摘　　要：目的观察骨保护素(OPG)全段甲状旁腺激素(iPTH)在慢性肾脏病(CKD)中的变化以及与骨密度(BMD)的相关性。方法采用ELASA法测定100例慢性肾脏病患者和健康体检人群的血清OPG和iPTH值。采用双能X线骨密度仪测定上述人群的1～4腰椎前后位BMD和T值。结果 CKD5期(Ccr<15mL/min)T值和BMD值与体检人群比较差异有统计学意义(P<0.05);CKD2～4期T值和BMD值与体检人群比较差异无统计学意义(P>0.05)。CKD3～5期患者血清OPG显著高于体检人群(P<0.05),CKD4、5期患者血清iPTH明显高于体检人群(P<0.01)。相关分析表明OPG和iPTH与骨密度相关。结论 CKD患者OPG和iPTH改变早于BMD和T值改变。Objective To observe the variances of Osteoprotegerin （OPG） and intact Parathyroid hormone （iPTH） in chronic kidney disease （CKD） patients. And to elucidate the relationship between the serum OPG and PTH with BMD. MethodsThe serum concentrations of OPG and iPTH in normal subjects and 100 CKD patients were measured using ELISA The lumbar BMD （L1～4） were measured using dual X ray absorptiometry （DEXA） in 100 CKD patients and 25 age-matched controls. ResultsThe BMD and T-score in CKD stages 5 were significantly lower than those of the sex-age matched group（P 0.05）. The serum concentrations of OPG in patients of CKD stage 3～5 were higher than those of the controls significantly （P 0.05）; Compared to controls, iPTH level in patients of CKD stage 4～5 was significantly elevated. ConclusionsSerum OPG and iPTH changed early than BMD in CKD patients.

关 键 词：慢性肾脏病 骨保护素 甲状腺旁腺激素 

分 类 号：R692[医药卫生—泌尿科学]