阿司匹林联合氯吡格雷治疗进展性缺血性脑卒中临床观察  

Clinical observation of curative effect of aspirin and clopidogrel in treating progressive ischemic stroke

作　　者：王增军[1] 田作蓉[1] 黄红娟[1] 

机构地区：[1]淮安市第二人民医院神经内科,江苏淮安223002

出　　处：《现代医药卫生》2010年第23期3562-3563,共2页Journal of Modern Medicine & Health

摘　　要：目的:观察阿司匹林单药及联合氯吡格雷在治疗进展性缺血性脑卒中的差异。方法:选择进展性缺血性脑卒中患者95例,随机分为两组:阿司匹林联合氯吡格雷为治疗组,阿司匹林单药治疗为对照组,均治疗30d,分别于治疗前及治疗15d、30d对患者进行欧洲卒中量表评分(ESS)、日常生活能力评分(ADL),以治疗30dESS增分率、ADL增分率作为主要疗效判断标准。结果:两组病例治疗前ESS、ADL评分差异无统计学意义,治疗15d、30d,ESS、ADL评分逐渐升高,治疗组ESS、ADL平分升高明显高于对照组,两组增分率比较,治疗15d后差异有统计学意义(P<0.05),治疗30天后P<0.01。结论:阿司匹林联合氯吡格雷治疗进展性缺血性脑卒中疗效明显高于单药阿司匹林。Objective：To observe the effect of the combination of aspirin with clopidogrel in treating progressive ischemic stroke.Methods：Ninety-five cases of progressive ischemic stroke were randomly selected and divided into two groups.The treatment group was given the combination of aspirin with clopidogrel and the control group received aspirin for one treatment course of 30 d.European stroke rating scale（ESS） and activities of daily living（ADL） were conducted before treatment and after 15 d and 30 d treatment.The increments of ESS and ADL on 30 d were used as the main criteria for judging the curative effect.Results：The difference of ESS and ADL scores had no statistical significance between the two groups before treatment.The scores of ESS and ADL gradually increased after 15 d and 30 d treatment,but the increment in the treatment group was obviously higher than that in the control group with statistical significance on 15 d（P0.05） and significantly difference on 30 d（P0.01）,respectively.No obvious side effects occurred.Conclusion：The combination of aspirin with clopidogrel is effective and safe in the treatment of progressive ischemic stroke,which is superior to single aspirin in curative effects.

关 键 词：进展性缺血性脑卒中 阿司匹林 氯吡格雷 

分 类 号：R5[医药卫生—内科学]