2-[[2'-氰基(1,1'-联苯基)-4-]甲基]巯基苯并噻唑的合成  

Synthesis of 2-[[2'-cyano(1,1'-biphenylyl)-4-]methyl]mercaptobenzothiazole

作　　者：晁淑军[1] 侯玉霞[2] 汪应灵[1] 

机构地区：[1]新乡医学院化学教研室,河南新乡453003 [2]河南科技学院化学化工学院,河南新乡453003

出　　处：《新乡医学院学报》2010年第6期557-558,共2页Journal of Xinxiang Medical University

基　　金：河南省基础与前沿技术研究计划项目(编号:092300410105);河南省教育厅自然科学研究计划资助项目(编号:2008A610007)

摘　　要：目的研究2-[[2'-氰基(1,1'-联苯基)-4-]甲基]巯基苯并噻唑的合成方法及最佳条件。方法通过2-巯基苯并噻唑与2-氰基-4'-溴甲基联苯在氢氧化钾/N,N-二甲基甲酰胺体系中进行缩合反应,制得目标化合物。结果经检测确定目标化合物为2-[[2'-氰基(1,1'-联苯基)-4-]甲基]巯基苯并噻唑,其反应的最佳条件为温度80℃,时间1.5h,2-氰基-4'-溴甲基联苯、2-巯基苯并噻唑和KOH的物质的量之比为111.5。结论通过不同反应条件进行缩合反应可以合成一种新的苯并噻唑衍生物。Objective To research the synthetic method and optimum reaction condition of 2-[[2＇-cyano（ 1,1＇-biphenyl） -4-]methyl]mercaptobenzothiazole. Methods The target compound was synthesized by the condensation of 2-mercapto-benzothiazole with 4-bromomethyl-2＇-cyanobiphenyl in N,N-dimethyl formamide in the presence of potassium hydroxide. The structure of the title compound was confirmed by EI-MS,1 H NMR,13 C NMR,IR and elementary analyses. Results The target compound was identified as 2-[[2＇-cyano（ 1,1＇-biphenylyl） -4-]methyl]mercaptobenzothiazole. The optimum reaction condition was 80 ？栬1. 5 hours and the mole ratio of 4-bromomethyl-2＇-cyanobiphenyl？？2-mercaptobenzothiazole and potassium hydroxide was 1：1：1. 5. Conclusion A kind of new benzothiazole derivative was synthesized by the condensation reaction under the different reaction conditions.

关 键 词：2-[[2'-氰基(1 1'-联苯基)-4-]甲基]巯基苯并噻唑 2-巯基苯并噻唑 2-氰基-4'-溴甲基联苯 缩合反应 

分 类 号：O626[理学—有机化学]