羟丁酸钠对小鼠体质量、自主活动和学习记忆的影响  

Effects of sodium oxybate on weight,autonomic activities,learning and memory in mice

作　　者：袁雪梅[1] 黄辉[2] 徐小林[2] 诸源江[1] 张科学[1] 徐佳[3] 陈银宝[2] 戴体俊[4] 

机构地区：[1]徐州医学院麻醉学院,江苏徐州221002 [2]徐州医学院公共卫生学院,江苏徐州221002 [3]徐州医学院临床医学二系,江苏徐州221002 [4]徐州医学院麻醉药理学教研室,江苏徐州221002

出　　处：《中国医院药学杂志》2010年第21期1803-1805,共3页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金资助项目(编号:30872432;30471657;39970715);江苏省自然科学基金资助项目(编号:BK200143);2009年江苏省高等学校大学生实践创新训练计划项目(编号:628)

摘　　要：目的:观察连续多次使用羟丁酸钠(SO)对幼龄小鼠体质量、自主活动和学习记忆的影响。方法:按分层随机区组设计将小鼠分为4组(n=20):生理盐水10mL.kg-1组(NS组),SO25,50,100mg.kg-1组(S025、SO50、SO100组),均为腹腔注射(ip)给药。第1～5天每隔24h给药一次,第6天停药并测量小鼠体质量、自主活动次数、避暗法及跳台法的潜伏期和错误次数。结果:与NS组比较,SO100组小鼠体质量降低(P<0.05),SO50、SO100组自主活动次数减少(P<0.01),避暗法及跳台法的潜伏期和错误次数差异无显著性。结论:多次使用SO可使小鼠体质量减轻,自主活动次数减少,但对学习记忆没有明显影响。OBJECTIVE To observe the effects of repeated adeministration of sodium oxybate （SO） on body weight, auto- nomic activities, learning and memory in young mice. METHODSS Eighty Kuming young mice were randomly divided into 4 groups of 20 animals each and treated with normal saline 10 mL·kg-1 , SO 25 mgokg1 , SO50 mgokg-1 and SO100 mg-kg-1 ip for NS, SO25 ,SO50, and SO100 groups respectively. The drug was given once a day from dl to d5. Then the body weight, fre- quency of autonomic activity, length of latency period and the numbers of error time in step-dowm test and step-through test were noticed. RESULTS As compared with group NS, SO100 group decreasaed body weight （P〈0. 05）, SO50 and SO100 groups reduced the numbers of autonomic activity （P〈0. 01 ）, but the length of latency and the numbers of error time did not have sta- tistical significance. CONCLUSION These data demonstrateld that repeated ip of SO did cause significant differences in body weight, autonomic activity, but not influence on the length of latency or the numbers of error time.

关 键 词：羟丁酸钠 体质量 自主活动 学习记忆 小鼠 

分 类 号：R966[医药卫生—药理学]