青藤碱微乳处方及其透皮性能研究  

Study on preparation of sinomenine microemulsion and its transdermal character

作　　者：刘鹏[1] 桂双英[1,2,3] 鲁传华[2,3] 彭代银[2,3] 齐雪萍[1] 潘恩媛[1] 程斌[1] 开伟华[1] 

机构地区：[1]安徽中医学院药学院,合肥230031 [2]安徽省115现代中药产业创新团队,合肥230031 [3]现代中药安徽省工程技术研究中心,合肥230031

出　　处：《中国新药杂志》2010年第20期1911-1914,1920,共5页Chinese Journal of New Drugs

基　　金：安徽省优秀青年科技基金(06043094);安徽省教育厅自然科学研究重点项目(KJ2007A121ZC)

摘　　要：目的:筛选青藤碱微乳最佳处方,同时考察不同体系的微乳体外透皮能力。方法:以大鼠离体皮肤渗透速率及累积渗透量为指标,采用均匀设计法确定最佳处方。结果:最佳处方为:聚山梨酯-20与乙醇为1∶2,含青藤碱2%,油酸2%,混合表面活性剂50%,水46%。结论:优选处方的青藤碱微乳透皮性能良好。Objective：To choose the optimum formulation of sinomenine microemulsion,and investigate in vitro transdermal delivery ability of the different system microemulsion.Methods：Homogeneous design was performed to optimize the formulation with permeation rate and accumulation osmolality as indexes by in vitro transdermal absorption with the skin of rats.Results：The optimum formulation were as follows：the ratio of Tween-20 to ethanol was 1∶2,sinomenine was 2%,oleic acid was 2%,mix surface active agent was 50% and water was 46%.Conclusion：The transdermal character of sinomenine microemulsion was good.

关 键 词：青藤碱微乳 伪三元相图 经皮吸收 

分 类 号：R943.4[医药卫生—药剂学]