丹参对非酒精性脂肪肝大鼠血清瘦素Ghrelin的影响  

Effects of Danshen on Non-alcoholic Fatty Liver in Serum Leptin Ghrelin

作　　者：莫新民[1] 刘锐[1] 李建平[2] 范娟娟[1] 甘国兴[1] 

机构地区：[1]湖南中医药大学,湖南长沙410007 [2]中南大学药学院,湖南长沙410013

出　　处：《中华中医药学刊》2010年第11期2252-2254,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:观察丹参对非酒精性脂肪肝模型大鼠血清瘦素及Ghrelin的影响。方法:采用高脂饲料建立SD大鼠非酒精性脂肪肝模型,并用丹参进行干预治疗4周,观察药物对大鼠肝脏组织病理变化、TG、TC水平,及血清瘦素、Ghrelin水平的影响。结果:与模型对照组比较,丹参治疗组大鼠肝脏组织TG、TC的水平显著降低(P<0.01),同时血清瘦素水平下降,Ghrelin水平升高(P<0.05)。结论:丹参可以明显改善非酒精性脂肪肝模型大鼠肝脏脂肪沉积,其机制可能与改善瘦素抵抗及升高血清Ghrelin浓度有关。Objective：To observe the effects of Danshen on non-alcoholic fatty liver rat leptin and Ghrelin in blood serum.Methods：SD rats non-alcoholic fatty liver disease model were established with high fat diet.To intervene with the Danshen treatment for 4 weeks,rat liver pathological changes,TG,TC level,and leptin,Ghrelin levels in serum were observed.Results：With the model control group,Danshen treated rats liver TG,TC level significantly lower（P 〈 0.01）,while reduction in the level of serum leptin,Ghrelin levels increased（P 〈 0.05）.Conclusion：Danshen can sig-nificantly improve the non-alcoholic fatty liver model of rat liver fat deposition and its mechanism may be related to im-proved leptin resistance and elevated serum Ghrelin concentrations.

关 键 词：非酒精性脂肪肝 丹参 瘦素 GHRELIN 

分 类 号：R285.5[医药卫生—中药学]