复方中药抗早孕的形态学研究  

Morphological Study of the Traditional Chinese Medicine on Termination of Early Pregnancy.

作　　者：马保华[1] 季黎明[2] 邴鲁军[1] 王哲民[3] 

机构地区：[1]山东医科大学组织胚胎学教研室,济南250012 [2]济南市第二人民医院妇产科 [3]山东省中医药研究所

出　　处：《中国计划生育学杂志》1999年第5期203-205,210,共4页Chinese Journal of Family Planning

摘　　要：为研究中药抗旱孕的作用机理,采用雌性金黄地鼠于受精后第4天灌服中药,每天2次,连续3天。结果:①抗早孕效果明显,孕鼠子宫串珠样隆起萎缩,消失;②石蜡切片观察子宫内膜上皮细胞排列紊乱,固有层出血;③超薄切片电镜观察上皮细胞纤毛消失,线粒体和核糖体增多;④亲和细胞化学技术观察,ConA、PNA、UEA等凝集素受体增多。结论:灌服中药使子宫内膜发生形态学改变,影响了胚胎生存发育的环境,出现明显的抗早孕作用。有意义的是在停药后第10天左右,实验动物全部恢复动情周期交配生仔,表明中药抗早孕作用是可逆的。The termination of early pregnancy was studied in morphology. The mated female hamsters were given traditional Chinese medicine orally in the dose of 10.5g/kg.on the 4th.d of gestation and dissected on the 3th.d after treatment. In the treatment groups, the results showed that the irregularity of epthelium and the disappearance of uterine glands and the bleeding in the endomter-ium of the uterine glands and the bleeding in the endomterium of the uterine could be seen. The staining intensity for Con A.PNA, UEA in each treated group was singnificantly higher than those in control group(P<0.01) .Present study indicated the traditional medicine Chinese could cause an increase in amount of the glycoproteins containing Con A PNA, and UEA receptors of the endometri-um.The traditional medicine Chinese could cause the disappearance of the epithelial cilia and an increase in amount of mitochondria and ribo-somes.On the 10th day, the fertility of the treated hamsters was recoved.

关 键 词：抗早孕 胚胎 凝集素 受体 复方中药 形态学 

分 类 号：R169.41[医药卫生—公共卫生与预防医学] R285.5