海洛因与吗啡依赖恒河猴的病理组织学研究  

HISTOPATHOLOGICAL STUDIES ON HEROIN - DEPENDENT ANDMORPHINE - DEPENDENT RHESUS MONKEYS

作　　者：王芳[1,2] 郭晓红 杨耘[1,2] 张晓冬[1,2] 高倩 张肇玖[1,2] 张正仙[1,2] 徐贵丽 蒋家雄[1,2] 

机构地区：[1]昆明医学院病理学教研室 [2]昆明医学院药物依赖研究所

出　　处：《中国药物依赖性杂志》1999年第2期98-102,共5页Chinese Journal of Drug Dependence

摘　　要：目的··：比较海洛因与吗啡恒河猴依赖模型。方法··：利用光镜对恒河猴海洛因及吗啡依赖形成过程中垂体、睾丸、肾上腺等器官组织进行病理形态观察。结果··：在注射海洛因３个月内，垂体从无明显病变转为个别嗜酸性细胞坏死到部分嗜酸性和嗜碱性细胞坏死；下丘脑从无明显病变转为少数神经细胞坏死；肾上腺从无明显病变转为个别束状带细胞水肿到大多数束状带细胞水肿；睾丸从无明显病变转为个别曲细精管萎缩，见成熟精子和间质细胞到大部分曲细精管萎缩到全部曲细精管萎缩，无成熟精子和间质细胞，且自然戒断３个月时垂体、睾丸的病变未得到恢复。注射吗啡３个月时，垂体仅有个别嫌色细胞水肿；下丘脑结构基本正常；睾丸仅为部分曲细精管萎缩，有成熟精子；肾上腺个别束状带细胞水肿，且自然戒断３个月时病变已恢复。结论··：海洛因依赖猴造成垂体、睾丸、肾上腺等组织器官损伤的程度比吗啡依赖猴的更重；在恒河猴海洛因依赖形成过程中，随注射时间延长，组织损伤程度加重。Objective: To compare the model of heroin-dependent rhesus monkeys with that of morphine-dependent rhesus monkeys. Method: The pathological morphology of pituitary,testes,adrenal etc. of heroin-dependent and morphine-dependent rhesus monkeys were reviewed by light microscope. Result: Within a period of 3 month injection of heroin,there were from no obvious pathological changes in pituitary to a very few acidophilic cell necrosis,to some acidophilic and basophilic cells necrosis; from no evident pathological changes in hypothalamus to few nervous cells necrosis; from no obvious pathological changes in adrenal to one or two-cell having gone hydropic degeneration in zona fasiculata, to most of cells hydropic degeneration; from no evident pathological changes in testes to very few seminiferous tubules atrophy,with mature spermatozoa and leydig cells, to most of seminiferous tubules atrophy,to all seminiferous tubules atrophy with old mature spermatozoa and leydig cells. These pathological changes of pituitary and testes hadn't been recovered on the third month of natural withdrawal. On the third month of injecting morphine,only one or two chromophobe cell of pituitary went hydropic degeneration. Strauctures of hypothalamus were generally normal; some seminiferous tubules of testes were atrophy, with mature spermatozoa; only a few cells in zona fasiculata of adrenal went hydropic degeneration.On the third month of natural withdrawal after injecting morphine,these pathological changes had been recovered in testes,pituitary and adrenal etc.Conclusion: The injury degree of organs or tissues was more serious in heroin - dependent monkeys than in morphine-dependent monkeys, especially on the pituitary,testes and adrenal. In the development of heroin-dependence, as times of injection increased,the injury d

关 键 词：海洛因依赖 吗啡依赖 病理组织学 

分 类 号：R595.502[医药卫生—内科学]