甲基苯丙胺条件性位置偏爱效应形成的神经机制  

NEUROMECHANISM UNDERLYING THE EFFECT OF CONDITIONED PLACE PREFERENCE OF METHAMPHETAMINE

作　　者：郭东文[1] 郑继旺[1] 

机构地区：[1]北京医科大学中国药物依赖性研究所

出　　处：《中国药物依赖性杂志》1999年第2期103-106,共4页Chinese Journal of Drug Dependence

摘　　要：目的··：本文探讨甲基苯丙胺（ＭＡ）的精神依赖性神经机制。方法··：采用条件性位置偏爱方法，大鼠脑内立体定位技术和脑内核团给药方法。利用ＡＢＣ免疫组织化学方法来显示脑内不同部位即刻早期基因ｃ－ｆｏｓ的表达情况。结果··：将ＭＡ注射到伏核（ＮＡｃ）内，在２０，４０，８０μｇ·ｋｇ－１剂量下对伴药盒产生了偏爱效应，且呈现出反相量效关系。而将相同剂量的ＭＡ注射到尾壳核（ＣＰｕ）中，未出现位置偏爱效应。ＭＡ位置偏爱模型形成后可诱导伏核、隔核、额前叶皮质、梨状皮质、导水管背外侧和腹外侧亚区等部位出现Ｆｏｓ阳性细胞。结论··：在ＭＡ的位置偏爱效应中ＮＡｃ起重要作用。ＭＡ的偏爱效应可能与特定脑区ｃ－ｆｏｓ基因的表达有一定关系。Objective: To study the neuro-mechanism underlying the effect of conditioned place preference (CPP) of methamphetamine (MA). Method: Use CPP paradigm, stereotaxic technique;microinject MA into brain's nucleus and test the expressions of c-fos immediate early gene in different rat brain areas after CPP testing of MA by ABC immunohistochemistry. Result: MA (20,40,80 gkg-1) microinjected into NAc, (20,40,80 gkg-1 ) produced place preference, the increased dose of MA resulted in an inversely related decrease in place preference,microinjecting MA (20,40, 80 gkg-1) into CPu failed to produce place preference; the number of the Fos positive nucleus increased in NAc, septum, prefrontal cortex, piriform cortex and periaquedutal gray. Conclusion : NAc plays an important role in MA CPP effect of rats. The Fos positive in some brain areas of rats indicated the psychic effect of MA related to the c-fos gene expression in special area of rat brain.

关 键 词：条件性 位置偏爱 甲基苯丙胺 精神依赖 

分 类 号：R595.502[医药卫生—内科学]