卡他林滴眼液在兔眼各组织中不同时间的分布  

Catalin ophthalmic solution distribution in various tissues of rabbit eye at different time

作　　者：孟宪敏[1,2] 赵佩琴[1,2] 张润武 陈翠真[1,2] 

机构地区：[1]北京市眼科研究所 [2]北京同仁医院核医学科

出　　处：《眼科》1999年第2期120-122,共3页Ophthalmology in China

摘　　要：目的：研究卡他林（Ｃａｔａｌｉｎ）滴眼液在兔眼角膜、虹膜、晶体、巩膜、房水和玻璃体组织中不同时间的分布，为评价滴眼液在内眼病治疗上的意义提供依据。方法：卡他林经１３１Ｉ标记，在滴入兔眼后０５、１、２、４和６小时测定兔眼各组织的１３１Ⅰ每分钟计数率（ＣＰＭ）。结果：经分析表明兔眼房水在２小时内药物浓度最高，但２小时之后迅速下降。晶体和玻璃体中药物浓度较低，并且变化不大，在不同的测定时间滴进晶体中的卡他林药水仅为０１１％～０４４％。结论：卡他林滴眼液容易通过角膜进入房水。To evaluate the therapeutic effect of ophthalmic solution on intraocular diseases,the distribution of catalin ophthalmic solution in various tissues of rabbit eye including the cornea,iris,lens,sclera,aqueous humor and the vitreous at different time was explored.Catalin was labeled by 131 Ⅰ and instilled into rabbit eye,counts per minuts (CPM) of the various tissues of rabbit eye were determined respectively at 0.5,1,2,4 and 6 hr after instilltion.It was showed that the concentration of the drug in aqueous humor was the hightest in 2 hr and falled down rapidlly 2 hr later,the concentration of the drug in the lens and vitreous was lower than other eye tissues and had less changes during the observation;the catalin content of lens instilled at different time was only 0.11%～0.44%.We could draw a conculusion that catalin ophthalmic solution is easy to enter into aqueous humor through cornea,while difficult to enter into lens.

关 键 词：白内障 药物疗法 药代动力学 卡他林滴眼液 

分 类 号：R969.1[医药卫生—药理学] R988.1[医药卫生—药学]